徳島大学 教育・研究者情報データベース(EDB)

1. (英) Shikata Eiji / (日) 四方 英二 / (読) しかた えいじ

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2. 宮本 健志([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])

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3. (英) Yamaguchi Tadashi / (日) 山口 真司 / (読) やまぐち ただし

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4. 山口 泉

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5. (英) Kagusa Hiroshi / (日) 鹿草 宏 / (読) かぐさ ひろし

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6. (英) Gotoh Daiki / (日) 後藤 大貴 / (読) ごとう だいき

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7. 島田 健司([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.脳·神経·精神科.脳神経外科])

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8. 多田 恵曜([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])

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9. 八木 謙次

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10. (日) 北里 慶子

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11. 兼松 康久

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12. 髙木 康志([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])

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(英) An imbalance between RAGE/MR/HMGB1 and ATP1α3 is associated with infammatory changes in rat brain harboring cerebral aneurysms prone to rupture

(英) An aneurysmal subarachnoid hemorrhage is a devastating event. To establish an effective therapeutic strategy, its pathogenesis must be clarified, particularly the pathophysiology of brain harboring intracranial aneurysms (IAs). To elucidate the pathology in brain harboring IAs, we examined the significance of the receptor for advanced glycation end-products (RAGE)/mineralocorticoid receptor (MR) pathway and Na/K-ATPase (ATP1α3). Ten-week-old female rats were subjected to oophorectomy as well as hypertension and hemodynamic changes to induce IAs, and were fed a high-salt diet. Brain damage in these rats was assessed by inflammatory changes in comparison to sham-operated rats fed a standard diet. Six weeks after IA induction (n = 30), irregular morphological changes, i.e., an enlarged vessel diameter and vascular wall, were observed in all of the left posterior cerebral arteries (Lt PCAs) prone to rupture. Approximately 20% of rats had ruptured IAs within 6 weeks. In brain harboring unruptured IAs at the PCA, the mRNA levels of RAGE and MR were higher, and that of ATP1α3 was lower than those in the sham-operated rats (p < 0.05, each). Immunohistochemically, elevated expression of RAGE and MR, and decreased expression of ATP1α3 were observed in the brain parenchyma adjacent to the Lt PCA, resulting in increased Iba-1 and S100B expression that reflected the inflammatory changes. There was no difference between the unruptured and ruptured aneurysm rat groups. Treatment with the MR antagonist esaxerenone abrogated these changes, and led to cerebral and vascular normalization and prolonged subarachnoid hemorrhage-free survival (p < 0.05). Regulation of the imbalance between the RAGE/MR pathway and ATP1α3 may help attenuate the damage in brain harboring IAs, and further studies are warranted to clarify the significance of the down-regulation of the MR/RAGE pathway and the up-regulation of ATP1α3 for attenuating the pathological changes in brain harboring IAs.

1. (英) Aneurysm, Ruptured
2. (英) Animals
3. (英) Brain
4. (英) Female
5. (英) HMGB1 Protein
6. (英) Intracranial Aneurysm
7. (英) Rats
8. (英) Receptor for Advanced Glycation End Products
9. (英) Receptors, Mineralocorticoid
10. (英) Sodium-Potassium-Exchanging ATPase
11. (英) Subarachnoid Hemorrhage

1. (英) Article.ELocationID: 161

2. (英) Article.ELocationID: 10.1186/s12974-022-02526-7

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) KeywordList.Keyword: ATP1α3

5. (英) KeywordList.Keyword: Brain damage

6. (英) KeywordList.Keyword: Cerebral aneurysm

7. (英) KeywordList.Keyword: HMGB1

8. (英) KeywordList.Keyword: MR

9. (英) KeywordList.Keyword: RAGE

10. (英) KeywordList.Keyword: SAH

11. (英) CoiStatement: The authors declare that they have no competing interests.