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著作: 佐藤 義秀/坂田 洞察/Bolst David/Simpson Edward/Guatelli Susanna/[芳賀 昭弘]/Development of a more accurate Geant4 quantum molecular dynamics model for hadron therapy/[Physics in Medicine and Biology]/[芳賀 昭弘]

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EID
392484
EOID
1063800
Map
0
LastModified
2022年12月8日(木) 11:52:25
Operator
芳賀 昭弘
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Owner
芳賀 昭弘
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨 国際共著(徳島大学内研究者と国外研究機関所属研究者との共同研究)
学究種別 推奨 博士前期課程学生による研究報告
組織 推奨
著者 必須
  1. (英) Sato Yoshihide / (日) 佐藤 義秀 / (読) さとう よしひで
    役割 任意
    貢献度 任意
    学籍番号 推奨 ****
  2. (英) Sakata Dousatsu / (日) 坂田 洞察 / (読) さかた どうさつ
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Bolst David
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Simpson Edward
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Guatelli Susanna
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 芳賀 昭弘([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.放射線科学系.医用画像物理学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Development of a more accurate Geant4 quantum molecular dynamics model for hadron therapy

副題 任意
要約 任意

(英) Objective: Although in heavy-ion therapy, the quantum molecular dynamics (QMD) model is one of the most fundamental physics models providing an accurate daughter- ion production yield in the final state, there are still non-negligible differences with the experimental results. The aim of this study is to improve fragment production in water phantoms by developing a more accurate QMD model in Geant4.Approach: A QMD model was developed by implementing modern Skyrme interaction parameter sets, as well as by incorporating with an ad hoc α-cluster model in the initial nuclear state. Two adjusting parameters were selected that can significantly affect the fragment productions in the QMD model: the radius to discriminate a cluster to which nucleons belong after the nucleus-nucleus reaction, denoted by R, and the squared standard deviation of the Gaussian packet, denoted by L. Squared Mahalanobiss distance of fragment yields and angular distributions with 1, 2, and the higher atomic number for the produced fragments were employed as objective functions, and multi- objective optimization (MOO), which make it possible to compare quantitatively the simulated production yields with the reference experimental data, was performed. Main results: The MOO analysis showed that the QMD model with modern Skyrme parameters coupled with the proposed α-cluster model, denoted as SkMα, can drastically improve light fragments yields in water. In addition, the proposed model reproduced the kinetic energy distribution of the fragments accurately. The optimized L in SkMα was confirmed to be realistic by the charge radii analysis in the ground state formation.Significance: The proposed framework using MOO was demonstrated to be very useful in judging the superiority of the proposed nuclear model. The optimized QMD model is expected to improve the accuracy of heavy-ion therapy dosimetry.

キーワード 推奨
  1. (英) Phantoms, Imaging
発行所 推奨
誌名 必須 Physics in Medicine and Biology(Hospital Physicists' Association)
(pISSN: 0031-9155, eISSN: 1361-6560)
ISSN 任意 1361-6560
ISSN: 0031-9155 (pISSN: 0031-9155, eISSN: 1361-6560)
Title: Physics in medicine and biology
Title(ISO): Phys Med Biol
Publisher: IOP Publishing Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 67
必須 15
必須 225001 225001
都市 任意
年月日 必須 2022年 10月 13日
URL 任意
DOI 任意 10.1088/1361-6560/ac9a9a    (→Scopusで検索)
PMID 任意 36240757    (→Scopusで検索)
CRID 任意
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Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
  1. 芳賀 昭弘([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.放射線科学系.医用画像物理学])
備考 任意
  1. (英) Article.ELocationID: 10.1088/1361-6560/ac9a9a

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) KeywordList.Keyword: fragmentation

  4. (英) KeywordList.Keyword: hadron therapy

  5. (英) KeywordList.Keyword: multi-objective optimization

  6. (英) KeywordList.Keyword: quantum molecular dynamics