徳島大学 教育・研究者情報データベース(EDB)

1. (英) Tsushima Fumihiko / (日) 津島 文彦 / (読) つしま ふみひこ

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. (英) Sakurai Jinkyo / (日) 櫻井 仁亨 / (読) さくらい じんきょう

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. 上杉 篤史([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔外科学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. (英) Oikawa Yu / (日) 及川 悠 / (読) おいかわ ゆう

   役割	任意
   貢献度	任意
   学籍番号	推奨

5. (英) Ohsako Toshimitu / (日) 大迫 利光 / (読) おおさこ としみつ

   役割	任意
   貢献度	任意
   学籍番号	推奨

6. (英) Mochizuki Yumi / (日) 望月 裕美 / (読) もちづき ゆみ

   役割	任意
   貢献度	任意
   学籍番号	推奨

7. (英) Hirai Hideaki / (日) 平井 秀明 / (読) ひらい ひであき

   役割	任意
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8. (英) Kayamori Kou / (日) 柏森 高 / (読) かやもり こう

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   貢献度	任意
   学籍番号	推奨

9. (英) Harada Hiroyuki / (日) 原田 浩之 / (読) はらだ ひろゆき

   役割	任意
   貢献度	任意
   学籍番号	推奨

(英) Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients

(英) Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear. We designed this study to examine the demographic and clinical characteristics of patients with OLP and evaluate the associated malignant transformation rate. A total of 565 patients with a clinical and histopathological diagnosis of OLP who presented at our department between 2001 and 2017 were retrospectively studied. Patients who had clinical and histopathological features of oral lichenoid lesions (OLLs) classified as oral lichenoid contact lesions, oral lichenoid drug reactions and oral lichenoid lesions of graft-versus-host disease were excluded. The study population included 123 men and 442 women aged 21-93 years (mean ± standard deviation, 60.5 ± 11.8). The 565 patients were followed up for a duration of 55.9 ± 45.3 months, during which 4 (0.7%) patients developed squamous cell carcinoma (SCC). In three of these 4 patients who developed SCC, the clinical type of OLP was the red type. Our results suggested that OLP was associated with a low risk of malignant transformation. We recommend regular follow-up for OLP patients and clear differentiation of oral epithelial dysplasia and OLLs to enable early detection of malignant transformation. Further investigation of the clinical risk factors associated with malignant transformation is necessary.

1. 癌(cancer)
2. (英) Oral mucosal disease / (日) 口腔粘膜疾患 / (読) こうくうねんまくしっかん

1. (英) Article.ELocationID: 10.1186/s12903-021-01652-7

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) KeywordList.Keyword: Malignant transformation

4. (英) KeywordList.Keyword: Oral lichen planus

5. (英) KeywordList.Keyword: Oral squamous cell carcinoma

6. (英) KeywordList.Keyword: Retrospective study