徳島大学 教育・研究者情報データベース(EDB)

1. (英) Kurosawa Mie

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2. (英) Shikama Yosuke

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3. (英) Furukawa Masae

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4. 新垣 理恵子

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5. 石丸 直澄([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])

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6. (英) Matsushita Kenji

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(英) Chemokines Up-Regulated in Epithelial Cells Control Senescence-Associated T Cell Accumulation in Salivary Glands of Aged and Sjögren's Syndrome Model Mice.

(英) Immunosenescence is characterized by age-associated changes in immunological functions. Although age- and autoimmune-related sialadenitis cause dry mouth (xerostomia), the roles of immunosenescence and cellular senescence in the pathogenesis of sialadenitis remain unknown. We demonstrated that acquired immune cells rather than innate immune cells infiltrated the salivary glands (SG) of aged mice. An analysis of isolated epithelial cells from SG revealed that the expression levels of the chemokine CXCL13 were elevated in aged mice. Senescence-associated T cells (SA-Ts), which secrete large amounts of atypical pro-inflammatory cytokines, are involved in the pathogenesis of metabolic disorders and autoimmune diseases. The present results showed that SA-Ts and B cells, which express the CXCL13 receptor CXCR5, accumulated in the SG of aged mice, particularly females. CD4 T cells derived from aged mice exhibited stronger in vitro migratory activity toward CXCL13 than those from young mice. In a mouse model of Sjögren's syndrome (SS), SA-Ts also accumulated in SG, presumably via CXCL12-CXCR4 signaling. Collectively, the present results indicate that SA-Ts accumulate in SG, contribute to the pathogenesis of age- and SS-related sialadenitis by up-regulating chemokines in epithelial cells, and have potential as therapeutic targets for the treatment of xerostomia caused by these types of sialadenitis.

1. (英) Animals
2. (英) Autoimmune Diseases
3. (英) B-Lymphocytes
4. (英) CD4-Positive T-Lymphocytes
5. (英) Cell Movement
6. (英) Cellular Senescence
7. (英) Chemokine CXCL13
8. (英) Chemokines
9. (英) Disease Models, Animal
10. (英) Epithelial Cells
11. 女性(female)
12. (英) Gene Expression Regulation
13. 男性(male)
14. (英) Mice
15. (英) Mice, Inbred C57BL
16. (英) Receptors, CXCR5
17. 唾液腺(salivary glands/->キーワード[唾液腺])
18. (英) Sialadenitis
19. シェーグレン症候群(Sjögren's syndrome)
20. Tリンパ球(T lymphocytes)
21. (英) Xerostomia

1. (英) Article.ELocationID: 2302

2. (英) Article.ELocationID: 10.3390/ijms22052302

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) KeywordList.Keyword: cellular senescence

5. (英) KeywordList.Keyword: chemokines

6. (英) KeywordList.Keyword: immunosenescence

7. (英) KeywordList.Keyword: sialadenitis

8. (英) KeywordList.Keyword: xerostomia