著作: Sato Mami/[新垣 理恵子]/Tawara Hiroaki/[常松 貴明]/[石丸 直澄]/Formation of Autoimmune Lesions Is Independent of Antibiotic Treatment in NOD Mice./[International Journal of Molecular Sciences]
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種別 | 必須 | 学術論文(審査論文) | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | ||||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | ||||
学究種別 | 推奨 | ||||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) Formation of Autoimmune Lesions Is Independent of Antibiotic Treatment in NOD Mice. |
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副題 | 任意 | ||||
要約 | 任意 |
(英) The relationship between autoimmunity and changes in intestinal microbiota is not yet fully understood. In this study, the role of intestinal microbiota in the onset and progression of autoimmune lesions in non-obese diabetic (NOD) mice was evaluated by administering antibiotics to alter their intestinal microenvironment. Flow cytometric analysis of spleen cells showed that antibiotic administration did not change the proportion or number of T and B cells in NOD mice, and pathological analysis demonstrated that autoimmune lesions in the salivary glands and in the pancreas were also not affected by antibiotic administration. These results suggest that the onset and progression of autoimmunity may be independent of enteral microbiota changes. Our findings may be useful for determining the appropriate use of antibiotics in patients with autoimmune diseases who are prescribed drugs to maintain systemic immune function. |
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キーワード | 推奨 | ||||
発行所 | 推奨 | ||||
誌名 | 必須 |
International Journal of Molecular Sciences(Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(pISSN: 1661-6596, eISSN: 1422-0067)
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巻 | 必須 | 22 | |||
号 | 必須 | 6 | |||
頁 | 必須 | 3239 3239 | |||
都市 | 任意 | ||||
年月日 | 必須 | 2021年 3月 22日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.3390/ijms22063239 (→Scopusで検索) | |||
PMID | 任意 | 33810172 (→Scopusで検索) | |||
CRID | 任意 | ||||
WOS | 任意 | ||||
Scopus | 任意 | ||||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
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