著作: Hasan Mahadi/Khatun Anowara/[小暮 健太朗]/Iontophoresis of Biological Macromolecular Drugs./[Pharmaceutics]
ヘルプを読む
「著作」（著作（著書，論文，レター，国際会議など））は，研究業績にかかる著作（著書，論文，レター，国際会議など）を登録するテーブルです． (この情報が属するテーブルの詳細な定義を見る)
- 項目名の部分にマウスカーソルを置いて少し待つと，項目の簡単な説明がツールチップ表示されます．
編集する
複製して登録
削除する| 種別 | 必須 | 総説·解説 | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 言語 | 必須 | 英語 | |||||||||||||||||||||||||||
| 招待 | 推奨 | ||||||||||||||||||||||||||||
| 審査 | 推奨 | ||||||||||||||||||||||||||||
| カテゴリ | 推奨 | ||||||||||||||||||||||||||||
| 共著種別 | 推奨 | ||||||||||||||||||||||||||||
| 学究種別 | 推奨 | ||||||||||||||||||||||||||||
| 組織 | 推奨 | ||||||||||||||||||||||||||||
| 著者 | 必須 |
|
|||||||||||||||||||||||||||
| 題名 | 必須 |
(英) Iontophoresis of Biological Macromolecular Drugs. |
|||||||||||||||||||||||||||
| 副題 | 任意 | ||||||||||||||||||||||||||||
| 要約 | 任意 |
(英) Over the last few decades, biological macromolecular drugs (e.g., peptides, proteins, and nucleic acids) have become a significant therapeutic modality for the treatment of various diseases. These drugs are considered superior to small-molecule drugs because of their high specificity and favorable safety profiles. However, such drugs are limited by their low oral bioavailability and short half-lives. Biological macromolecular drugs are typically administrated via invasive methods, e.g., intravenous or subcutaneous injections, which can be painful and induce needle phobia. Noninvasive transdermal delivery is an alternative administration route for the local and systemic delivery of biological macromolecular drugs. However, a challenge with the noninvasive transdermal delivery of biological macromolecular drugs is the outermost layer of the skin, known as the stratum corneum, which is a physical barrier that restricts the entry of extraneous macromolecules. Iontophoresis (IP) relies on the application of a low level of electricity for transdermal drug delivery, in order to facilitate the skin permeation of hydrophilic and charged molecules. The IP of several biological macromolecular drugs has recently been investigated. Herein, we review the IP-mediated noninvasive transdermal delivery of biological macromolecular drugs, their routes of skin permeation, their underlying mechanisms, and their advance applications. |
|||||||||||||||||||||||||||
| キーワード | 推奨 | ||||||||||||||||||||||||||||
| 発行所 | 推奨 | ||||||||||||||||||||||||||||
| 誌名 | 必須 |
Pharmaceutics(Molecular Diversity Preservation International)
(pISSN: 1999-4923)
|
|||||||||||||||||||||||||||
| 巻 | 必須 | 14 | |||||||||||||||||||||||||||
| 号 | 必須 | 3 | |||||||||||||||||||||||||||
| 頁 | 必須 | 525 525 | |||||||||||||||||||||||||||
| 都市 | 任意 | ||||||||||||||||||||||||||||
| 年月日 | 必須 | 2022年 2月 26日 | |||||||||||||||||||||||||||
| URL | 任意 | ||||||||||||||||||||||||||||
| DOI | 任意 | 10.3390/pharmaceutics14030525 (→Scopusで検索) | |||||||||||||||||||||||||||
| PMID | 任意 | 35335900 (→Scopusで検索) | |||||||||||||||||||||||||||
| CRID | 任意 | ||||||||||||||||||||||||||||
| WOS | 任意 | ||||||||||||||||||||||||||||
| Scopus | 任意 | ||||||||||||||||||||||||||||
| 評価値 | 任意 | ||||||||||||||||||||||||||||
| 被引用数 | 任意 | ||||||||||||||||||||||||||||
| 指導教員 | 推奨 | ||||||||||||||||||||||||||||
| 備考 | 任意 |
|
|||||||||||||||||||||||||||