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著作: [福田 達也]/Oku Naoto/[小暮 健太朗]/Application and utility of liposomal neuroprotective agents and biomimetic nanoparticles for the treatment of ischemic stroke/[Pharmaceutics]

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EID
390036
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1056741
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2022年8月23日(火) 19:49:11
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大家 隆弘
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小暮 健太朗
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種別 必須 総説·解説
言語 必須 英語
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著者 必須
  1. 福田 達也
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Oku Naoto
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    貢献度 任意
    学籍番号 推奨
  3. 小暮 健太朗([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学])
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題名 必須

(英) Application and utility of liposomal neuroprotective agents and biomimetic nanoparticles for the treatment of ischemic stroke

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(英) Ischemic stroke is still one of the leading causes of high mortality and severe disability worldwide. Therapeutic options for ischemic stroke and subsequent cerebral ischemia/reperfusion injury remain limited due to challenges associated with drug permeability through the blood-brain barrier (BBB). Neuroprotectant delivery with nanoparticles, including liposomes, offers a promising solution to address this problem, as BBB disruption following ischemic stroke allows nanoparticles to pass through the intercellular gaps between endothelial cells. To ameliorate ischemic brain damage, a number of nanotherapeutics encapsulating neuroprotective agents, as well as surface-modified nanoparticles with specific ligands targeting the injured brain regions, have been developed. Combination therapy with nanoparticles encapsulating neuroprotectants and tissue plasminogen activator (t-PA), a globally approved thrombolytic agent, has been demonstrated to extend the narrow therapeutic time window of t-PA. In addition, the design of biomimetic drug delivery systems (DDS) employing circulating cells (e.g., leukocytes, platelets) with unique properties has recently been investigated to overcome the injured BBB, utilizing these cells' inherent capability to penetrate the ischemic brain. Herein, we review recent findings on the application and utility of nanoparticle DDS, particularly liposomes, and various approaches to developing biomimetic DDS functionalized with cellular membranes/membrane proteins for the treatment of ischemic stroke.

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誌名 必須 Pharmaceutics(Molecular Diversity Preservation International)
(pISSN: 1999-4923)
ISSN 任意 1999-4923
ISSN: 1999-4923 (eISSN: 1999-4923)
Title: Pharmaceutics
Title(ISO): Pharmaceutics
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 14
必須 2
必須 361 361
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年月日 必須 2022年 2月 4日
URL 任意
DOI 任意 10.3390/pharmaceutics14020361    (→Scopusで検索)
PMID 任意 35214092    (→Scopusで検索)
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  1. (英) Article.ELocationID: 361

  2. (英) Article.ELocationID: 10.3390/pharmaceutics14020361

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Review

  5. (英) KeywordList.Keyword: biomimetic DDS

  6. (英) KeywordList.Keyword: blood-brain barrier

  7. (英) KeywordList.Keyword: cerebral ischemia/reperfusion injury

  8. (英) KeywordList.Keyword: intermembrane protein transfer

  9. (英) KeywordList.Keyword: ischemic stroke

  10. (英) KeywordList.Keyword: leukocytes

  11. (英) KeywordList.Keyword: liposomes

  12. (英) KeywordList.Keyword: nanoparticles