徳島大学 教育・研究者情報データベース(EDB)

1. (英) Nakanishi Nobuto / (日) 中西 信人

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2. (英) Tsutsumi Rie

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3. (英) Hara Kanako

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4. (英) Matsuo Masafumi

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5. 阪上 浩([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学]/[徳島大学.糖尿病臨床・研究開発センター])

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6. 大藤 純([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.救急集中治療医学]/[徳島大学.病院.中央診療施設等.救急集中治療部])

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(英) Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome.

(英) Titin is a giant protein that functions as a molecular spring in sarcomeres. Titin interconnects the contraction of actin-containing thin filaments and myosin-containing thick filaments. Titin breaks down to form urinary titin N-fragments, which are measurable in urine. Urinary titin N-fragment was originally reported to be a useful biomarker in the diagnosis of muscle dystrophy. Recently, the urinary titin N-fragment has been increasingly gaining attention as a novel biomarker of muscle atrophy and intensive care unit-acquired weakness in critically ill patients, in whom titin loss is a possible pathophysiology. Furthermore, several studies have reported that the urinary titin N-fragment also reflected muscle atrophy and weakness in patients with chronic illnesses. It may be used to predict the risk of post-intensive care syndrome or to monitor patients' condition after hospital discharge for better nutritional and rehabilitation management. We provide several tips on the use of this promising biomarker in post-intensive care syndrome.

1. (英) PublicationType: Journal Article

2. (英) PublicationType: Review