徳島大学 教育・研究者情報データベース(EDB)

1. (英) Morita Yutaka

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2. 西條 敦郎

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3. 軒原 浩

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4. 三橋 惇志([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域総合医療学])

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5. 米田 浩人([徳島大学.病院.診療科.内科.呼吸器・膠原病内科])

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6. 大塚 憲司

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7. 荻野 広和([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.内科.呼吸器・膠原病内科])

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8. 坂東 良美([徳島大学.病院.中央診療施設等.病理部])

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9. 西岡 安彦([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])

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(英) Radiation therapy induces an abscopal effect and upregulates programmed death-ligand 1 expression in a patient with non-small cell lung cancer.

(英) T cells, occasionally resulting in a systemic immune response to the tumor outside of the treatment field. The phenomenon of tumor regression at the site distant from irradiated fields is known as the abscopal effect. Several case reports have indicated a potential role of RT in overcoming primary and acquired resistance against immune checkpoint inhibitors in non-small cell lung cancer (NSCLC) and melanoma patients. We herein report an NSCLC patient who developed acquired resistance to an RT-induced abscopal effect and subsequently experienced reactivation of the systemic antitumor immune response by pembrolizumab, an antiprogrammed death 1 antibody. In this case, RT not only induced an abscopal effect but also upregulated the programmed death-ligand 1 expression outside of the irradiated field when the patient developed resistance to the abscopal effect. This case can facilitate our understanding of the mechanism underlying the RT-induced systemic immune response against cancer cells and adaptive resistance mechanism of cancer cells from immune surveillance. These findings highlight the promising results of current clinical trials combining RT and immune checkpoint inhibitors. Ongoing clinical trials will further establish evidence supporting combination therapy with RT and immune checkpoint inhibitors.

1. (英) B7-H1 Antigen
2. (英) CD8-Positive T-Lymphocytes
3. (英) Carcinoma, Non-Small-Cell Lung
4. (英) Humans
5. (英) Lung Neoplasms

1. (英) PublicationType: Case Reports