著作: Tabassum Ara/小野 智子/Hasan M/[大園 瑞音]/[小暮 健太朗]/Protective effects of liposomes encapsulating ferulic acid against CCl4-induced oxidative liver damage in vivo rat model/[Journal of Clinical Biochemistry and Nutrition]/[小暮 健太朗]
ヘルプを読む
「著作」（著作（著書，論文，レター，国際会議など））は，研究業績にかかる著作（著書，論文，レター，国際会議など）を登録するテーブルです． (この情報が属するテーブルの詳細な定義を見る)
- 項目名の部分にマウスカーソルを置いて少し待つと，項目の簡単な説明がツールチップ表示されます．
編集する
複製して登録
削除する| 種別 | 必須 | 学術論文(審査論文) | |||
|---|---|---|---|---|---|
| 言語 | 必須 | 英語 | |||
| 招待 | 推奨 | ||||
| 審査 | 推奨 | ||||
| カテゴリ | 推奨 | ||||
| 共著種別 | 推奨 | 国内共著(徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) | |||
| 学究種別 | 推奨 | ||||
| 組織 | 推奨 | ||||
| 著者 | 必須 | ||||
| 題名 | 必須 |
(英) Protective effects of liposomes encapsulating ferulic acid against CCl4-induced oxidative liver damage in vivo rat model |
|||
| 副題 | 任意 | ||||
| 要約 | 任意 |
(英) Antioxidants are useful for the treatment of oxidative stress mediated liver damage. A naturally occurring antioxidant γ-oryzanol is rapidly hydrolyzed to its active hydrophobic metabolite, ferulic acid, inside the body. Limitations associated with the hydrophobicity of ferulic acid can be overcome by encapsulating in a liposomal formulation. As intravenously administered nanoparticles (including liposomes) can effectively reach the liver, such systems may be suitable drug delivery carriers to treat liver injury. In this study, we prepared a liposomal formulation of ferulic acid (ferulic-lipo) and examined its effects on liver damage induced by CCl. Ferulic-lipo were ~100 nm in size and drug encapsulation efficiency was about 92%. Ferulic-lipo showed potent scavenging efficacy against hydroxyl radical compared to α-tocopherol liposomes. Ferulic-lipo significantly prevented CCl-mediated cytotoxicity in human hepatocarcinoma cells. Furthermore, intravenous administration of ferulic-lipo significantly reduced alanine aminotransferase and aspartate amino transferase levels in a rat model of liver injury. CCl-mediated reactive oxygen species generation in liver was also reduced by intravenous administration of ferulic-lipo. Hepatoprotective effects of ferulic-lipo were demonstrated by histological observation of CCl-induced liver tissue damage. Therefore, ferulic-lipo exhibit potent antioxidative capacity and were suggested to be an effective formulation for prevention of oxidative damage of liver tissue. |
|||
| キーワード | 推奨 | ||||
| 発行所 | 推奨 | ||||
| 誌名 | 必須 |
Journal of Clinical Biochemistry and Nutrition(日本酸化ストレス学会)
(pISSN: 0912-0009, eISSN: 1880-5086)
|
|||
| 巻 | 必須 | 72 | |||
| 号 | 必須 | 1 | |||
| 頁 | 必須 | 46 53 | |||
| 都市 | 任意 | ||||
| 年月日 | 必須 | 2023年 1月 初日 | |||
| URL | 任意 | ||||
| DOI | 任意 | 10.3164/jcbn.22-37 (→Scopusで検索) | |||
| PMID | 任意 | 36777075 (→Scopusで検索) | |||
| CRID | 任意 | 1390576118542264832 | |||
| WOS | 任意 | ||||
| Scopus | 任意 | 2-s2.0-85146549828 | |||
| 評価値 | 任意 | ||||
| 被引用数 | 任意 | ||||
| 指導教員 | 推奨 |
|
|||
| 備考 | 任意 |
|
|||