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著作: [福田 大受]/Pham PT/[佐田 政隆]/Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases/[Journal of Atherosclerosis and Thrombosis]

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EID
384441
EOID
1033666
Map
0
LastModified
2022年4月17日(日) 17:25:36
Operator
大家 隆弘
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TRUE
Censor
0
Owner
佐田 政隆
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 福田 大受
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Pham PT
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    学籍番号 推奨
  3. 佐田 政隆([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases

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(英) Sterile chronic inflammation causes cardiometabolic disorders; however, the mechanisms are not fully understood. Previous studies have demonstrated the degradation of cells/tissues in the vasculature and metabolic organs in lifestyle-associated diseases, such as diabetes and hyperlipidemia, suggesting the release and/or accumulation of nucleic acids from damaged cells. DNA is indispensable for life; however, DNA fragments, especially those from pathogens, strongly induce inflammation by the activation of DNA sensors. Growing evidence suggests that DNA-sensing mechanisms, which are normally involved in self-defense against pathogens as the innate immune system, are associated with the progression of inflammatory diseases in response to endogenous DNA fragments. There are several types of DNA sensors in our bodies. Toll-like receptor 9 (TLR9)-one of the most studied DNA sensors-recognizes DNA fragments in endosome. In addition, stimulator of interferon genes (STING), which has recently been extensively investigated, recognizes cyclic GMP-AMP (cGAMP) generated from DNA fragments in the cytosol. Both TLR9 and STING are known to play pivotal roles in host defense as the innate immune system. However, recent studies have indicated that the activation of these DNA sensors in immune cells, such as macrophages, promotes inflammation leading to the development of vascular and metabolic diseases associated with lifestyle. In this review, we discuss recent advances in determining the roles of DNA sensors in these disease contexts. Revealing a novel mechanism of sterile chronic inflammation regulated by DNA sensors might facilitate clinical interventions for these health conditions.

キーワード 推奨
  1. (英) Animals
  2. (英) DNA
  3. (英) Humans
  4. (英) Immunity, Innate
  5. (英) Metabolic Diseases
  6. (英) Signal Transduction
  7. (英) Vascular Diseases
発行所 推奨
誌名 必須 Journal of Atherosclerosis and Thrombosis(日本動脈硬化学会)
(pISSN: 1340-3478, eISSN: 1880-3873)
ISSN 任意 1880-3873
ISSN: 1340-3478 (pISSN: 1340-3478, eISSN: 1880-3873)
Title: Journal of atherosclerosis and thrombosis
Title(ISO): J Atheroscler Thromb
Supplier: 一般社団法人 日本動脈硬化学会
Publisher: Japan Atherosclerosis Society
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 29
必須 3
必須 297 307
都市 任意
年月日 必須 2022年 3月 1日
URL 任意
DOI 任意 10.5551/jat.RV17059    (→Scopusで検索)
PMID 任意 34248111    (→Scopusで検索)
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  1. (英) Article.ELocationID: 10.5551/jat.RV17059

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Review

  4. (英) KeywordList.Keyword: Atherosclerosis

  5. (英) KeywordList.Keyword: DNA sensor

  6. (英) KeywordList.Keyword: Inflammation

  7. (英) KeywordList.Keyword: Insulin resistance

  8. (英) KeywordList.Keyword: STING

  9. (英) KeywordList.Keyword: TLR9