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著作: [坂根 亜由子]/Yoshizawa Shin/Yokota Hideo/[佐々木 卓也]/Dancing Styles of Collective Cell Migration: Image-Based Computational Analysis of JRAB/MICAL-L2./[Frontiers in Cell and Developmental Biology]

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EID
381473
EOID
1018521
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0
LastModified
2021年9月1日(水) 14:25:22
Operator
三木 ちひろ
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TRUE
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佐々木 卓也
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
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著者 必須
  1. 坂根 亜由子([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.生化学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Yoshizawa Shin
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Yokota Hideo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 佐々木 卓也([徳島大学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Dancing Styles of Collective Cell Migration: Image-Based Computational Analysis of JRAB/MICAL-L2.

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要約 任意

(英) Collective cell migration is observed during morphogenesis, angiogenesis, and wound healing, and this type of cell migration also contributes to efficient metastasis in some kinds of cancers. Because collectively migrating cells are much better organized than a random assemblage of individual cells, there seems to be a kind of order in migrating clusters. Extensive research has identified a large number of molecules involved in collective cell migration, and these factors have been analyzed using dramatic advances in imaging technology. To date, however, it remains unclear how myriad cells are integrated as a single unit. Recently, we observed unbalanced collective cell migrations that can be likened to either precision dancing or , Japanese traditional dancing similar to the style at Rio Carnival, caused by the impairment of the conformational change of JRAB/MICAL-L2. This review begins with a brief history of image-based computational analyses on cell migration, explains why quantitative analysis of the stylization of collective cell behavior is difficult, and finally introduces our recent work on JRAB/MICAL-L2 as a successful example of the multidisciplinary approach combining cell biology, live imaging, and computational biology. In combination, these methods have enabled quantitative evaluations of the "dancing style" of collective cell migration.

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誌名 必須 Frontiers in Cell and Developmental Biology(Frontiers Media S.A.)
(eISSN: 2296-634X)
ISSN 任意 2296-634X
ISSN: 2296-634X (eISSN: 2296-634X)
Title: Frontiers in cell and developmental biology
Title(ISO): Front Cell Dev Biol
Publisher: Frontiers Media SA
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 6
必須 ---
必須 4 4
都市 任意
年月日 必須 2018年 2月 5日
URL 任意
DOI 任意 10.3389/fcell.2018.00004    (→Scopusで検索)
PMID 任意 29468157    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意 2-s2.0-85042102406
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被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.3389/fcell.2018.00004

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Review

  4. (英) KeywordList.Keyword: JRAB/MICAL-L2

  5. (英) KeywordList.Keyword: collective cell migration

  6. (英) KeywordList.Keyword: computational analysis

  7. (英) KeywordList.Keyword: conformational change

  8. (英) KeywordList.Keyword: optical flow

  9. (英) KeywordList.Keyword: rab GTPases