著作: [坂根 亜由子]/Yoshizawa Shin/Yokota Hideo/[佐々木 卓也]/Dancing Styles of Collective Cell Migration: Image-Based Computational Analysis of JRAB/MICAL-L2./[Frontiers in Cell and Developmental Biology]
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削除する| 種別 | 必須 | 学術論文(審査論文) | |||
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| 言語 | 必須 | 英語 | |||
| 招待 | 推奨 | ||||
| 審査 | 推奨 | ||||
| カテゴリ | 推奨 | ||||
| 共著種別 | 推奨 | ||||
| 学究種別 | 推奨 | ||||
| 組織 | 推奨 | ||||
| 著者 | 必須 | ||||
| 題名 | 必須 |
(英) Dancing Styles of Collective Cell Migration: Image-Based Computational Analysis of JRAB/MICAL-L2. |
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| 副題 | 任意 | ||||
| 要約 | 任意 |
(英) Collective cell migration is observed during morphogenesis, angiogenesis, and wound healing, and this type of cell migration also contributes to efficient metastasis in some kinds of cancers. Because collectively migrating cells are much better organized than a random assemblage of individual cells, there seems to be a kind of order in migrating clusters. Extensive research has identified a large number of molecules involved in collective cell migration, and these factors have been analyzed using dramatic advances in imaging technology. To date, however, it remains unclear how myriad cells are integrated as a single unit. Recently, we observed unbalanced collective cell migrations that can be likened to either precision dancing or , Japanese traditional dancing similar to the style at Rio Carnival, caused by the impairment of the conformational change of JRAB/MICAL-L2. This review begins with a brief history of image-based computational analyses on cell migration, explains why quantitative analysis of the stylization of collective cell behavior is difficult, and finally introduces our recent work on JRAB/MICAL-L2 as a successful example of the multidisciplinary approach combining cell biology, live imaging, and computational biology. In combination, these methods have enabled quantitative evaluations of the "dancing style" of collective cell migration. |
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| キーワード | 推奨 | ||||
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| 誌名 | 必須 |
Frontiers in Cell and Developmental Biology(Frontiers Media S.A.)
(eISSN: 2296-634X)
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| 巻 | 必須 | 6 | |||
| 号 | 必須 | --- | |||
| 頁 | 必須 | 4 4 | |||
| 都市 | 任意 | ||||
| 年月日 | 必須 | 2018年 2月 5日 | |||
| URL | 任意 | ||||
| DOI | 任意 | 10.3389/fcell.2018.00004 (→Scopusで検索) | |||
| PMID | 任意 | 29468157 (→Scopusで検索) | |||
| CRID | 任意 | ||||
| WOS | 任意 | ||||
| Scopus | 任意 | 2-s2.0-85042102406 | |||
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| 指導教員 | 推奨 | ||||
| 備考 | 任意 |
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