徳島大学 教育・研究者情報データベース(EDB)

1. (英) Ikegame Akishige

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2. (英) Inoue Yusuke

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3. (英) Hata Makoto

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4. (英) Sugasaki Motoki

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5. (英) Yoshida Hiroko

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6. (英) Ogasa Satiko

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7. (英) Nakao Takayuki

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8. (英) Ikegame Kazuhiro

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9. 藤井 志朗([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.内科.血液内科])

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10. (英) Shibata Eriko

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11. 長井 幸二郎

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12. (英) Takayama Tetsuji

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13. 安倍 正博([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.血液・内分泌代謝内科学])

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(英) The ADVIA2120i parameter Revised %MICRO is a surrogate marker of schistocyte formation after hematopoietic stem cell transplantation.

(英) Objectives : Hematopoietic stem cell transplantation (HSCT)-associated thrombotic microangiopathy (TA-TMA) is an important early post-treatment condition. This study evaluated the Revised %MICRO, a parameter obtained from the ADVIA 2120i automated blood cell counter, as a surrogate marker of the schistocyte ratio. We hypothesized that individual differences between the %MICRO value and schistocyte ratio would remain constant. Design and Methods: EDTA-2K-treated peripheral blood samples were collected from 19 patients who underwent allogeneic HSCT from April 2014 to September 2018. First, the baseline difference, X, was calculated using a sample from the first day after HSCT as X = %MICRO (first day) - schistocyte ratio (first day). Next, the Revised %MICRO for each subsequent day was calculated as Revised %MICRO = %MICRO - X. We evaluated correlations of the schistocyte ratio with the calculated %MICRO and Revised %MICRO and the RBC fragment, RBC distribution width, %MICRO and Revised %MICRO data obtained from the ADVIA 2120i. Results : The mean schistocyte percentage and Revised %MICRO were both 0.4% 0.6. RBC fragments correlated weakly with the %MICRO and schistocyte ratio, respectively (r = 0.162 and r = 0.771, respectively), whereas the Revised %MICRO correlated strongly with the schistocyte ratio (r = 0.893). Conclusion : The Revised %MICRO appears to be a good surrogate of the schistocyte ratio in a clinical setting. J. Med. Invest. 67 : 250-254, August, 2020.

1. (英) Article.ELocationID: 10.2152/jmi.67.250

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) KeywordList.Keyword: ADVIA2120i

4. (英) KeywordList.Keyword: Hematopoietic stem cell transplantation

5. (英) KeywordList.Keyword: RBC fragments

6. (英) KeywordList.Keyword: Revised %MICRO

7. (英) KeywordList.Keyword: Schistocytes