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著作: Khan Luqman/Sato Katsumi/okuyama Shinichi/Kobayashi Takeshi/Ohashi Kazumasa/Hirasaka Katsuya/[二川 健]/Takada Kunio/Higashitani Atsushi/Abiko Kenji/Ultra-high-purity iron is a novel and very compatible biomaterial/[Journal of the Mechanical Behavior of Biomedical Materials]

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EID
378519
EOID
1015961
Map
0
LastModified
2021年8月22日(日) 21:12:44
Operator
大家 隆弘
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Owner
二川 健
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Khan Luqman
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Sato Katsumi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) okuyama Shinichi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Kobayashi Takeshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Ohashi Kazumasa
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Hirasaka Katsuya
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 二川 健([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.生体栄養学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Takada Kunio
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Higashitani Atsushi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  10. (英) Abiko Kenji
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Ultra-high-purity iron is a novel and very compatible biomaterial

副題 任意
要約 任意

(英) Metals and alloys are used widely in bone prosthetic materials, stents and dental tissue reconstructions. The most common materials are stainless steels and cobalt-chromium-nickel and titanium alloys. These alloys can be easily deformed but are hard to break. However, their affinity for cells and tissues is very low. In addition, they can sometimes provoke unexpected metal allergies. Iron is an abundant trace element essential for humans. However, excess amounts in particular of Fe ions are toxic. We previously succeeded in obtaining 99.9996% ultra-high-purity iron (ABIKO iron). The chemical properties of ABIKO iron are completely different from that of conventional pure iron. For example, the reaction rate in hydrochloric acid is very slow and there is barely any corrosion. Here, we found that, in the absence of any type of coating, mammalian cells could easily attach to, and normally proliferate and differentiate on, ABIKO iron. On the other hand, cell densities and proliferation rate of the surfaces of plates made from Co-Cr-Mo or Ti-6Al-4V were significantly reduced. In addition, several stress and iron response genes, HSP70, SOD1, ATM and IRP2 did not change in the cells on ABIKO iron, while these genes were induced with exogenous application of FeSO. Cells also secreted and fastened some organics on ABIKO iron. In vitro collagen binding assay showed that ABIKO iron binds higher amount of collagens. These findings highlight ABIKO iron as a novel biocompatible prosthetic material.

キーワード 推奨
  1. (英) Alloys
  2. (英) Animals
  3. (英) Biocompatible Materials
  4. (英) Cobalt
  5. (英) Corrosion
  6. (英) Humans
  7. (英) Iron
  8. (英) Materials Testing
  9. (英) Titanium
発行所 推奨
誌名 必須 Journal of the Mechanical Behavior of Biomedical Materials([Elsevier])
(pISSN: 1751-6161, eISSN: 1878-0180)
ISSN 任意 1878-0180
ISSN: 1751-6161 (pISSN: 1751-6161, eISSN: 1878-0180)
Title: Journal of the mechanical behavior of biomedical materials
Title(ISO): J Mech Behav Biomed Mater
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 106
必須 ---
必須 103744 103744
都市 任意
年月日 必須 2020年 6月 初日
URL 任意
DOI 任意 10.1016/j.jmbbm.2020.103744    (→Scopusで検索)
PMID 任意 32250954    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: S1751-6161(20)30298-8

  2. (英) Article.ELocationID: 10.1016/j.jmbbm.2020.103744

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  5. (英) KeywordList.Keyword: Cell differentiation

  6. (英) KeywordList.Keyword: Cell proliferation

  7. (英) KeywordList.Keyword: Fe

  8. (英) KeywordList.Keyword: Mesenchymal stem cells

  9. (英) KeywordList.Keyword: Myoblast

  10. (英) CoiStatement: Declaration of competing interest The authors declare no competing interests.