377921: [田原強]/Zhang Zhouen/Ohno Masahiro/Hirao Yukako/Hosaka Nami/Doi Hisashi/Suzuki Masaaki/Onoe Hirotaka/A novel (11)C-labeled thymidine analog, [(11)C]AZT, for tumor imaging by positron emission tomography./[EJNMMI Research]

著作: [田原強]/Zhang Zhouen/Ohno Masahiro/Hirao Yukako/Hosaka Nami/Doi Hisashi/Suzuki Masaaki/Onoe Hirotaka/A novel (11)C-labeled thymidine analog, [(11)C]AZT, for tumor imaging by positron emission tomography./[EJNMMI Research]

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種別

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学術論文(審査論文)

言語

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英語

招待

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審査

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カテゴリ

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共著種別

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学究種別

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組織

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著者

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田原強([徳島大学.先端研究推進センター.バイオイメージング研究部門])

役割任意

貢献度任意

学籍番号推奨
(英) Zhang Zhouen

役割任意

貢献度任意

学籍番号推奨
(英) Ohno Masahiro

役割任意

貢献度任意

学籍番号推奨
(英) Hirao Yukako

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貢献度任意

学籍番号推奨
(英) Hosaka Nami

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貢献度任意

学籍番号推奨
(英) Doi Hisashi

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貢献度任意

学籍番号推奨
(英) Suzuki Masaaki

役割任意

貢献度任意

学籍番号推奨
(英) Onoe Hirotaka

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貢献度任意

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題名

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(英) A novel (11)C-labeled thymidine analog, [(11)C]AZT, for tumor imaging by positron emission tomography.

副題

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要約

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(英) Tumors can be detected by PET using [(11)C]AZT; therefore, [(11)C]AZT could be useful as a novel PET tracer for tumor imaging in vivo.

(日) In PET studies, C6 and HeLa tumors in mice were clearly visualized using [(11)C]AZT. Time-activity curves using [(11)C]AZT showed that the accumulation of radioactivity in tumors plateaued at 10 min after injection and persisted for 60 min, while most of the radioactivity in other tissues was rapidly excreted into the urine. In various tissues of the body, tumor tissue showed the highest radioactivity at 80 min after injection (five to six times higher uptake than that of blood). Compared with tumor tissue, uptake was lower in other proliferative tissues such as the spleen, intestine, and bone marrow, resulting in a high tumor-to-bone marrow ratio. Cellular uptake of [(11)C]AZT in C6 cells was completely blocked by the application of thymidine, strongly indicating the specific involvement of nucleoside transporters. In contrast, the time-activity curve of [(11)C]d4T in the tumor showed transient and rapid excretion with almost no obvious tumor tissue accumulation.

キーワード

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発行所

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誌名

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EJNMMI Research(Springer Berlin)

(eISSN: 2191-219X)

ISSN	任意	2191-219X ISSN: 2191-219X (eISSN: 2191-219X) Title: EJNMMI research Title(ISO): EJNMMI Res Publisher: Springer (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

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号

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頁

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---

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年月日

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2015年 9月 4日

URL

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DOI

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10.1186/s13550-015-0124-0 (→Scopusで検索)

PMID

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26337804 (→Scopusで検索)

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Scopus

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備考

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(英) PublicationType: Journal Article

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

著作: [田原強]/Zhang Zhouen/Ohno Masahiro/Hirao Yukako/Hosaka Nami/Doi Hisashi/Suzuki Masaaki/Onoe Hirotaka/A novel (11)C-labeled thymidine analog, [(11)C]AZT, for tumor imaging by positron emission tomography./[EJNMMI Research]

著作: [田原 強]/Zhang Zhouen/Ohno Masahiro/Hirao Yukako/Hosaka Nami/Doi Hisashi/Suzuki Masaaki/Onoe Hirotaka/A novel (11)C-labeled thymidine analog, [(11)C]AZT, for tumor imaging by positron emission tomography./[EJNMMI Research]

著作: [田原強]/Zhang Zhouen/Ohno Masahiro/Hirao Yukako/Hosaka Nami/Doi Hisashi/Suzuki Masaaki/Onoe Hirotaka/A novel (11)C-labeled thymidine analog, [(11)C]AZT, for tumor imaging by positron emission tomography./[EJNMMI Research]