377914: Vong Kenward/[田原強]/Urano Sayaka/Nasibullin Igor/Tsubokura Kazuki/Nakao Yoichi/Kurbangalieva Almira/Onoe Hirotaka/Watanabe Yasuyoshi/Tanaka Katsunori/Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy./[Science Advances]

著作: Vong Kenward/[田原強]/Urano Sayaka/Nasibullin Igor/Tsubokura Kazuki/Nakao Yoichi/Kurbangalieva Almira/Onoe Hirotaka/Watanabe Yasuyoshi/Tanaka Katsunori/Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy./[Science Advances]

ヘルプを読む

「著作」（著作（著書，論文，レター，国際会議など））は，研究業績にかかる著作（著書，論文，レター，国際会議など）を登録するテーブルです． (この情報が属するテーブルの詳細な定義を見る)

項目名の部分にマウスカーソルを置いて少し待つと，項目の簡単な説明がツールチップ表示されます．

この情報をEDB閲覧画面で開く

EID: 377914
EOID: 1072975
Map: 0
LastModified: 2023年4月28日(金) 15:06:13
Operator: 田原強
Avail: TRUE
Censor: 承認済
Owner: 田原強
Read: 継承
Write: 継承
Delete: 継承

種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

推奨

カテゴリ

推奨

共著種別

推奨

学究種別

推奨

組織

推奨

著者

必須

(英) Vong Kenward

役割任意第1著者(主著者)

貢献度任意

学籍番号推奨
田原強([徳島大学.先端研究推進センター.バイオイメージング研究部門])

役割任意第1著者(主著者)

貢献度任意

学籍番号推奨
(英) Urano Sayaka

役割任意

貢献度任意

学籍番号推奨
(英) Nasibullin Igor

役割任意

貢献度任意

学籍番号推奨
(英) Tsubokura Kazuki

役割任意

貢献度任意

学籍番号推奨
(英) Nakao Yoichi

役割任意

貢献度任意

学籍番号推奨
(英) Kurbangalieva Almira

役割任意

貢献度任意

学籍番号推奨
(英) Onoe Hirotaka

役割任意

貢献度任意

学籍番号推奨
(英) Watanabe Yasuyoshi

役割任意

貢献度任意

学籍番号推奨
(英) Tanaka Katsunori

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy.

副題

任意

要約

任意

(英) This study presents the early framework of selective cell tagging (SeCT) therapy, which is the concept of preferentially labeling specific cells in vivo with chemical moieties that can elicit a therapeutic response. Using glycosylated artificial metalloenzyme (GArM)-based protein labeling, this study reports two separate functional strategies. In one approach, early tumor onset can be suppressed by tagging cancer cells in living mice with an integrin-blocking cyclic-Arg-Gly-Asp (cRGD) moiety, thereby disrupting cell adhesion onto the extracellular matrix. In another approach, tumor growth in mice can be reduced by tagging with a cytotoxic doxorubicin moiety. Subsequent cell death occurs following internalization and drug release. Overall, experiments have shown that mouse populations receiving the mixture of SeCT labeling reagents exhibited a significant delay/reduction in tumor onset and growth compared with controls. Highlighting its adaptability, this work represents a foundational step for further development of SeCT therapy and its potential therapeutic applications.

キーワード

推奨

発行所

推奨

誌名

必須

Science Advances(American Association for the Advancement of Science)

(eISSN: 2375-2548)

ISSN	任意	2375-2548 ISSN: 2375-2548 (eISSN: 2375-2548) Title: Science advances Title(ISO): Sci Adv Publisher: American Association for the Advancement of Science (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

必須

号

必須

頁

必須

---

都市

任意

年月日

必須

2021年 4月 23日

URL

任意

DOI

任意

10.1126/sciadv.abg4038 (→Scopusで検索)

PMID

任意

33893089 (→Scopusで検索)

CRID

任意

WOS

任意

Scopus

任意

評価値

任意

被引用数

任意

指導教員

推奨

備考

任意

(英) PublicationType: Journal Article

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

著作: Vong Kenward/[田原強]/Urano Sayaka/Nasibullin Igor/Tsubokura Kazuki/Nakao Yoichi/Kurbangalieva Almira/Onoe Hirotaka/Watanabe Yasuyoshi/Tanaka Katsunori/Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy./[Science Advances]

著作: Vong Kenward/[田原 強]/Urano Sayaka/Nasibullin Igor/Tsubokura Kazuki/Nakao Yoichi/Kurbangalieva Almira/Onoe Hirotaka/Watanabe Yasuyoshi/Tanaka Katsunori/Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy./[Science Advances]

著作: Vong Kenward/[田原強]/Urano Sayaka/Nasibullin Igor/Tsubokura Kazuki/Nakao Yoichi/Kurbangalieva Almira/Onoe Hirotaka/Watanabe Yasuyoshi/Tanaka Katsunori/Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy./[Science Advances]