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著作: [良元 俊昭]/[吉川 幸造]/[東島 潤]/[宮谷 知彦]/[徳永 卓哉]/[西 正暁]/[髙須 千絵]/[柏原 秀也]/[武原 悠花子]/[島田 光生]/Bevacizumab-associated intestinal perforation and perioperative complications in patients receiving bevacizumab./[Annals of Gastroenterological Surgery]

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EID
377847
EOID
1011817
Map
0
LastModified
2021年8月5日(木) 16:10:41
Operator
柏原 秀也
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TRUE
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Owner
島田 光生
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 良元 俊昭([徳島大学.病院.栄養部])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 吉川 幸造([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 東島 潤
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 宮谷 知彦
    役割 任意
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    学籍番号 推奨
  5. 徳永 卓哉([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.外科.消化器・移植外科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 西 正暁([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.外科.消化器・移植外科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 髙須 千絵([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. 柏原 秀也([徳島大学.病院.中央診療施設等.地域外科診療部])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. 武原 悠花子([徳島大学.病院.診療科.第一外科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  10. 島田 光生([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
    役割 任意
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    学籍番号 推奨
題名 必須

(英) Bevacizumab-associated intestinal perforation and perioperative complications in patients receiving bevacizumab.

副題 任意
要約 任意

(英) The purposes of this study are to present cases of emergency surgery in which gastrointestinal perforation occurred during bevacizumab administration, consider the indications for emergency surgery, and examine the safety of scheduled surgery after a washout period for bevacizumab. (a) We retrospectively investigated seven patients who underwent emergency surgery for bevacizumab-associated intestinal perforation. (b) We investigated 104 patients with advanced colorectal cancer treated with neoadjuvant therapy who underwent surgery from 2008 to 2018, retrospectively. (a) In the seven patients undergoing emergency surgery for gastrointestinal perforation, the median bevacizumab administration and washout periods were 16 weeks and 24 days, respectively. A stoma was created in all patients except in those who were not candidates. Two patients developed postoperative abdominal abscesses, and two patients died from perioperative sepsis and gastrointestinal bleeding, respectively; both of these patients had poor performance status. (b) In patients receiving bevacizumab (n = 45) and patients treated with bevacizumab-free regimens as neoadjuvant therapy (n = 59), 31 and 52 patients received chemoradiotherapy, respectively. We found no correlation with postoperative complications with or without bevacizumab. The surgical indications should be considered carefully in patients with gastrointestinal perforation secondary to bevacizumab administration. Meanwhile, after appropriate cessation time, scheduled surgery following bevacizumab administration is feasible.

キーワード 推奨
発行所 推奨
誌名 必須 Annals of Gastroenterological Surgery([John Wiley & Sons, Inc.])
(eISSN: 2475-0328)
ISSN 任意 2475-0328
ISSN: 2475-0328 (eISSN: 2475-0328)
Title: Annals of gastroenterological surgery
Title(ISO): Ann Gastroenterol Surg
Publisher: Wiley-Blackwell Publishing Ltd
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 4
必須 2
必須 151 155
都市 任意
年月日 必須 2020年 2月 12日
URL 任意
DOI 任意 10.1002/ags3.12312    (→Scopusで検索)
PMID 任意 32258980    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1002/ags3.12312

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) KeywordList.Keyword: bevacizumab

  4. (英) KeywordList.Keyword: cancer

  5. (英) KeywordList.Keyword: emergencies

  6. (英) KeywordList.Keyword: perforation

  7. (英) KeywordList.Keyword: postoperative complications

  8. (英) CoiStatement: Funding: None. Conflicts of Interest: Authors declare no conflicts of interest for this article. Author Contribution: Toshiaki Yoshimoto: Manuscript writing, analysis, operating surgeon. Kozo Yoshikawa: Manuscript editor, operating surgeon. Jun Higashijima: Operating surgeon. Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara and Yukako Takehara: Attending physicians of the presented patient. Mitsuo Shimada: Supervisor. Ethical Approval: All procedures were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki declaration of 1964 and later revisions (Review board: Tokushima clinical trial management system (ToCMS); approval number: 3215). Informed consent or substitute for it was obtained from all patients for being included in the study.