377726: [後藤正和]/Shibahara Yukiko/Baciu Cristina/Allison Frances/Yeung Jonathan C/Darling Gail E/Liu Mingyao/Prognostic Impact of CXCR7 and CXCL12 Expression in Patients with Esophageal Adenocarcinoma./[Annals of Surgical Oncology]

著作: [後藤正和]/Shibahara Yukiko/Baciu Cristina/Allison Frances/Yeung Jonathan C/Darling Gail E/Liu Mingyao/Prognostic Impact of CXCR7 and CXCL12 Expression in Patients with Esophageal Adenocarcinoma./[Annals of Surgical Oncology]

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EID: 377726
EOID: 1013321
Map: 0
LastModified: 2021年8月12日(木) 12:52:34
Operator: 大家隆弘
Avail: TRUE
Censor: 0
Owner: 後藤正和
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

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カテゴリ

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共著種別

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学究種別

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組織

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著者

必須

後藤正和([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学])

役割任意

貢献度任意

学籍番号推奨
(英) Shibahara Yukiko

役割任意

貢献度任意

学籍番号推奨
(英) Baciu Cristina

役割任意

貢献度任意

学籍番号推奨
(英) Allison Frances

役割任意

貢献度任意

学籍番号推奨
(英) Yeung Jonathan C

役割任意

貢献度任意

学籍番号推奨
(英) Darling Gail E

役割任意

貢献度任意

学籍番号推奨
(英) Liu Mingyao

役割任意

貢献度任意

学籍番号推奨

題名

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(英) Prognostic Impact of CXCR7 and CXCL12 Expression in Patients with Esophageal Adenocarcinoma.

副題

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要約

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(英) High CXCR7 expression was associated with poor prognosis in patients with EAC, and high expression of CXCR7 with its ligand CXCL12 had a stronger association with prognosis. Further study of this potential biomarker using whole tissue samples and a larger sample size is warranted.

(日) High CXCR7 expression was significantly associated with lymphatic invasion (present vs absent, P = 0.005) and higher number of lymph node metastases (pN0-1 vs pN2-3, P = 0.0014). Patients with high CXCR7 expression (n = 23) were associated with worse overall (OS) and disease-free survival (DFS) (P = 0.0221, P = 0.0090, respectively), and patients with high CXCL12 (n = 24) tended to have worse OS and DFS (P = 0.1091, P = 0.1477, respectively). High expression of both CXCR7 and CXCL12 was an independent prognostic factor for OS and DFS on multivariate analysis (HR = 0.3, 95% CI: 0.1-0.9, P = 0.0246, HR = 0.3, 95% CI: 0.1-0.8, P = 0.0134, respectively).

キーワード

推奨

(英) Adenocarcinoma
(英) Chemokine CXCL12
(英) Esophageal Neoplasms
(英) Humans
(英) Lymphatic Metastasis
(英) Prognosis
(英) Receptors, CXCR
(英) Receptors, CXCR4

発行所

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誌名

必須

Annals of Surgical Oncology(Society of Surgical Oncology (U.S.))

(pISSN: 1068-9265, eISSN: 1534-4681)

ISSN	任意	1534-4681 ISSN: 1068-9265 (pISSN: 1068-9265, eISSN: 1534-4681) Title: Annals of surgical oncology Title(ISO): Ann Surg Oncol Supplier: Springer Online Journal Archive Publisher: Springer (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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4943 4951

都市

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年月日

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2021年 3月 11日

URL

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DOI

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10.1245/s10434-021-09775-5 (→Scopusで検索)

PMID

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33709176 (→Scopusで検索)

CRID

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WOS

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Scopus

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被引用数

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指導教員

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備考

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(英) PublicationType: Journal Article

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

著作: [後藤正和]/Shibahara Yukiko/Baciu Cristina/Allison Frances/Yeung Jonathan C/Darling Gail E/Liu Mingyao/Prognostic Impact of CXCR7 and CXCL12 Expression in Patients with Esophageal Adenocarcinoma./[Annals of Surgical Oncology]

著作: [後藤 正和]/Shibahara Yukiko/Baciu Cristina/Allison Frances/Yeung Jonathan C/Darling Gail E/Liu Mingyao/Prognostic Impact of CXCR7 and CXCL12 Expression in Patients with Esophageal Adenocarcinoma./[Annals of Surgical Oncology]

著作: [後藤正和]/Shibahara Yukiko/Baciu Cristina/Allison Frances/Yeung Jonathan C/Darling Gail E/Liu Mingyao/Prognostic Impact of CXCR7 and CXCL12 Expression in Patients with Esophageal Adenocarcinoma./[Annals of Surgical Oncology]