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著作: [髙須 千絵]/[西 正暁]/[吉川 幸造]/[徳永 卓哉]/[柏原 秀也]/[良元 俊昭]/[島田 光生]/Impact of sidedness of colorectal cancer on tumor immunity./[PLoS ONE]

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EID
377017
EOID
1009763
Map
0
LastModified
2021年7月20日(火) 14:49:15
Operator
吉川 幸造
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TRUE
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Owner
吉川 幸造
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種別 必須 学術論文(紀要その他)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 髙須 千絵([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 西 正暁([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.外科.消化器・移植外科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 吉川 幸造([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 徳永 卓哉([徳島大学.病院.中央診療施設等.地域外科診療部])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 柏原 秀也([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.外科.消化器・移植外科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 良元 俊昭([徳島大学.病院.栄養部])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 島田 光生([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Impact of sidedness of colorectal cancer on tumor immunity.

副題 任意
要約 任意

(英) Clinical and molecular characteristics differ between right-sided and left-sided colorectal cancer (CRC). This study aimed to clarify the correlation between CRC sidedness and tumor immunity. A total of 102 patients who underwent curative colectomy for stage II/III CRC were included in this study. The expression of programmed cell death (PD)-1, PD1-ligand 1 (PD-L1), forkhead box P3 (Foxp3), transforming growth factor (TGF)-β, and indoleamine-pyrrole 2,3-dioxygenase (IDO) were examined using immunohistochemistry and the relationships between sidedness and several prognostic factors were examined. Clinicopathological factors were not significantly different between right- and left-sided CRC. The tumor immunity-related molecule PD-L1 was more highly expressed in right-sided than in left-sided CRC (62.9% vs. 30.6%, p<0.01). No significant difference was found in overall survival (OS) and disease-free survival (DFS) by sidedness. PD-1 and Foxp3 expression were significant prognostic factors for OS. Lymph node metastasis (N), lymphatic invasion (ly), and PD-L1 expression were significant prognostic factors for DFS. In right-sided CRC, IDO-positive patients had a poor OS (p<0.05), and IDO was the only independent prognostic indicator for OS. N and venous invasion were identified as independent prognostic indicators for DFS. In left-sided CRC, univariate analysis identified PD-1, PD-L1, and Foxp3 expression as significant predictors of poor OS. Multivariate analysis confirmed PD-L1 expression as an independent prognostic indicator. N, ly, and PD-L1 expression levels were identified as significant predictors of poor DFS. The prognostic factors were IDO in right-sided CRC and PD-L1 and Foxp3 in left-sided CRC. These findings indicated that tumor immunity might play different roles depending upon sidedness. Tumor location may be an important factor to consider when assessing immune response and therapeutic decisions in CRC patients.

キーワード 推奨
  1. (英) Adult
  2. (英) Aged
  3. (英) Aged, 80 and over
  4. (英) B7-H1 Antigen
  5. (英) Biomarkers, Tumor
  6. (英) Colorectal Neoplasms
  7. (英) Disease-Free Survival
  8. (英) Female
  9. (英) Forkhead Transcription Factors
  10. (英) Gene Expression Regulation, Neoplastic
  11. (英) Humans
  12. (英) Indoleamine-Pyrrole 2,3,-Dioxygenase
  13. (英) Male
  14. (英) Middle Aged
  15. (英) Neoplasm Staging
  16. (英) Prognosis
  17. (英) Programmed Cell Death 1 Receptor
  18. (英) Transforming Growth Factor beta
  19. (英) Up-Regulation
発行所 推奨
誌名 必須 PLoS ONE(Public Library of Science)
(eISSN: 1932-6203)
ISSN 任意 1932-6203
ISSN: 1932-6203 (eISSN: 1932-6203)
Title: PloS one
Title(ISO): PLoS One
Publisher: PLOS
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 15
必須 10
必須 e0240408 e0240408
都市 任意
年月日 必須 2020年 10月 12日
URL 任意
DOI 任意 10.1371/journal.pone.0240408    (→Scopusで検索)
PMID 任意 33045001    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1371/journal.pone.0240408

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) CoiStatement: The authors have declared that no competing interests exist.