374771: Kimura Yuichi/Izumiya Yasuhiro/Araki Satoshi/Yamamura Satoru/Hanatani Shinsuke/Onoue Yoshiro/Ishida Toshifumi/Arima Yuichiro/Nakamura Taishi/Yamamoto Eiichiro/Senokuchi Takafumi/Yoshizawa Tatsuya/[佐田政隆]/Kim-Mitsuyama Shokei/Nakagata Naomi/Bober Eva/Braun Thomas/Kaikita Koichi/Yamagata Kazuya/Tsujita Kenichi/Sirt7 Deficiency Attenuates Neointimal Formation Following Vascular Injury by Modulating Vascular Smooth Muscle Cell Proliferation/[Circulation Journal]

著作: Kimura Yuichi/Izumiya Yasuhiro/Araki Satoshi/Yamamura Satoru/Hanatani Shinsuke/Onoue Yoshiro/Ishida Toshifumi/Arima Yuichiro/Nakamura Taishi/Yamamoto Eiichiro/Senokuchi Takafumi/Yoshizawa Tatsuya/[佐田政隆]/Kim-Mitsuyama Shokei/Nakagata Naomi/Bober Eva/Braun Thomas/Kaikita Koichi/Yamagata Kazuya/Tsujita Kenichi/Sirt7 Deficiency Attenuates Neointimal Formation Following Vascular Injury by Modulating Vascular Smooth Muscle Cell Proliferation/[Circulation Journal]

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EID: 374771
EOID: 1025584
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LastModified: 2021年12月21日(火) 15:22:54
Operator: 佐田政隆
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種別

必須

学術論文(審査論文)

言語

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英語

招待

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審査

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Peer Review

カテゴリ

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共著種別

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学究種別

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組織

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著者

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(英) Kimura Yuichi

役割任意

貢献度任意

学籍番号推奨
(英) Izumiya Yasuhiro

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貢献度任意

学籍番号推奨
(英) Araki Satoshi

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貢献度任意

学籍番号推奨
(英) Yamamura Satoru

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貢献度任意

学籍番号推奨
(英) Hanatani Shinsuke

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貢献度任意

学籍番号推奨
(英) Onoue Yoshiro

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学籍番号推奨
(英) Ishida Toshifumi

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学籍番号推奨
(英) Arima Yuichiro

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学籍番号推奨
(英) Nakamura Taishi

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学籍番号推奨
(英) Yamamoto Eiichiro

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学籍番号推奨
(英) Senokuchi Takafumi

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学籍番号推奨
(英) Yoshizawa Tatsuya

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貢献度任意

学籍番号推奨
佐田政隆([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])

役割任意

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学籍番号推奨
(英) Kim-Mitsuyama Shokei

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(英) Nakagata Naomi

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(英) Bober Eva

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(英) Braun Thomas

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(英) Kaikita Koichi

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(英) Yamagata Kazuya

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学籍番号推奨
(英) Tsujita Kenichi

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学籍番号推奨

題名

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(英) Sirt7 Deficiency Attenuates Neointimal Formation Following Vascular Injury by Modulating Vascular Smooth Muscle Cell Proliferation

副題

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要約

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(英) Sirt7 is a recently identified sirtuin and has important roles in various pathological conditions, including cancer progression and metabolic disorders. It has previously been reported that Sirt7 is a key molecule in acute myocardial wound healing and pressure overload-induced cardiac hypertrophy. In this study, the role of Sirt7 in neointimal formation after vascular injury is investigated.Methods and Results:Systemic (Sirt7) and smooth muscle cell-specific Sirt7-deficient mice were subjected to femoral artery wire injury. Primary vascular smooth muscle cells (VSMCs) were isolated from the aorta of wild type (WT) and Sirt7mice and their capacity for cell proliferation and migration was compared. Sirt7 expression was increased in vascular tissue at the sites of injury. Sirt7mice demonstrated significant reduction in neointimal formation compared to WT mice. In vitro, Sirt7 deficiency attenuated the proliferation of serum-induced VSMCs. Serum stimulation-induced upregulation of cyclins and cyclin-dependent-kinase 2 (CDK2) was significantly attenuated in VSMCs of Sirt7compared with WT mice. These changes were accompanied by enhanced expression of the microRNA 290-295 cluster, the translational negative regulator of CDK2, in VSMCs of Sirt7mice. It was confirmed that smooth muscle cell-specific Sirt7-deficient mice showed significant reduction in neointima compared with control mice. Sirt7 deficiency attenuates neointimal formation after vascular injury. Given the predominant role in vascular neointimal formation, Sirt7 is a potentially suitable target for treatment of vascular diseases.

キーワード

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発行所

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誌名

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Circulation Journal([社団法人日本循環器学会])

(pISSN: 1346-9843, eISSN: 1347-4820)

ISSN	任意	1346-9843 ISSN: 1346-9843 (pISSN: 1346-9843, eISSN: 1347-4820) Title: Circulation journal : official journal of the Japanese Circulation Society Title(ISO): Circ J Supplier: 社団法人日本循環器学会 Publisher: Japanese Circulation Society/Nihon Junkanki Gakkai (NLM Catalog) (Webcat Plus) (医中誌Web) (J-STAGE) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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2232 2240

都市

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年月日

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2021年 11月 25日

URL

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DOI

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10.1253/circj.CJ-20-0936 (→Scopusで検索)

PMID

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33678753 (→Scopusで検索)

CRID

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Scopus

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評価値

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被引用数

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指導教員

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備考

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(英) Article.ELocationID: 10.1253/circj.CJ-20-0936
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) KeywordList.Keyword: Neointimal formation
(英) KeywordList.Keyword: Sirtuin
(英) KeywordList.Keyword: Smooth muscle cell

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