徳島大学 教育・研究者情報データベース(EDB)

1. (英) Bando Ryota

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2. 大塚 秀樹([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.放射線科学系.画像医学・核医学]/[徳島大学.医学部.保健学科.放射線技術科学専攻.診療放射線技術学講座])

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3. 大谷 環樹([徳島大学.放射線総合センター])

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4. (英) Matsuda Noritake

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5. (英) Azane Shota

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6. (英) Kunikane Yamato

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7. (英) Otomi Yoichi

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8. 佐光 亘

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9. 和泉 唯信([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床神経科学]/[徳島大学.病院.診療科.内科.脳神経内科])

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10. 原田 雅史([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学])

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(英) A new quantitative index in the diagnosis of Parkinson syndrome by dopamine transporter single-photon emission computed tomography.

(英) Dopamine transporter single-photon emission computed tomography (DAT SPECT) has been widely used to diagnose Parkinson syndrome. Using the standardized uptake value (SUV) of DAT SPECT, we propose "functional dopamine transporter volume (f-DTV)" as a new quantitative index to evaluate the three-dimensional volume of functional dopamine transporters and assess its diagnostic ability in differentiating dopaminergic neurodegenerative diseases (dNDD) from non-dNDD. Seventy-nine patients were enrolled (42 dNDD, 37 non-dNDD; 38 men; age 24-88 years). We analyzed seven quantitative indices. The specific binding ratio (SBR) was calculated using a program specialized for DAT SPECT (SBR_Bolt). The SUVmax, SUVpeak, and SUVmean were calculated using a quantification program for bone SPECT. SBR_SUV was calculated by dividing striatal SUVmean by the average of background SUVmean. The cutoff value of the active dopamine transporter level was examined using three methods (threshold of 40% of SUVmax, SUV 2, and SUV 3) to calculate the active dopamine transporter volume (ADV). The f-DTV was calculated by multiplying ADV and SUV. We assessed the correlations between SBR_Bolt and SBR_SUV, and compared the mean value of each index between the dNDD and non-dNDD groups. The abilities of SBR_Bolt, SBR_SUV, SUVmax, SUVpeak, SUVmean, ADV, and f-DTV in differentiating dNDD from non-dNDD were determined by the area under the receiver operating curve (AUC) generated by the receiver operating characteristics analysis. The SBR_Bolt and SBR_SUV highly correlated with each other (r = 0.71). The cutoff value of the active dopamine transporter level was determined as SUV 3. All seven quantitative indices showed lower values in the dNDD group than in the non-dNDD group, and the difference between the two groups was statistically significant (p < 0.05). Sensitivity, specificity, and AUC of f-DTV were slightly lower than those of SBR_Bolt (71%, 79%, and 0.81, respectively, for f-DTV, and 81%, 84%, 0.88, respectively, for SBR_Bolt). The difference in AUC between f-DTV and SBR_Bolt was not statistically significant. This study demonstrates the utility of f-DTV as a novel quantitative index for evaluating the three-dimensional volume of functional dopamine transporters, and that f-DTV has almost the same diagnostic ability to differentiate dNDD from non-dNDD using DAT SPECT.

1. (英) Adult
2. (英) Aged
3. (英) Aged, 80 and over
4. (英) Biological Transport
5. (英) Diagnosis, Differential
6. (英) Dopamine Plasma Membrane Transport Proteins
7. 女性(female)
8. (英) Humans
9. (英) Iodine Radioisotopes
10. 男性(male)
11. (英) Middle Aged
12. (英) Nortropanes
13. パーキンソン病(Parkinson's disease)
14. (英) Phantoms, Imaging
15. (英) ROC Curve
16. (英) Retrospective Studies
17. (英) Tomography, Emission-Computed, Single-Photon

1. (日) 責任著者corresponding author:大塚秀樹

2. (英) Article.ELocationID: 10.1007/s12149-021-01592-w

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) KeywordList.Keyword: Active dopamine transporter volume

5. (英) KeywordList.Keyword: Dopamine transporter SPECT

6. (英) KeywordList.Keyword: Functional dopamine transporter volume

7. (英) KeywordList.Keyword: Parkinson syndrome

8. (英) KeywordList.Keyword: SUV