著作: Tanioka Daisuke/[近久 幸子]/[清水 紀之]/[志内 哲也]/Sakai Noriaki/Nishino Seiji/[勢井 宏義]/Intracranial mast cells contribute to the control of social behavior in male mice./[Behavioural Brain Research]
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種別 | 必須 | 学術論文(審査論文) | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | ||||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | ||||
学究種別 | 推奨 | ||||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) Intracranial mast cells contribute to the control of social behavior in male mice. |
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副題 | 任意 | ||||
要約 | 任意 |
(英) Mast cells (MCs) exist intracranially and have been reported to affect higher brain functions in rodents. However, the role of MCs in the regulation of emotionality and social behavior is unclear. In the present study, using male mice, we examined the relationship between MCs and social behavior and investigated the underlying mechanisms. Wild-type male mice intraventricularly injected with a degranulator of MCs exhibited a marked increase in a three-chamber sociability test. In addition, removal of MCs in Mast cell-specific Toxin Receptor-mediated Conditional cell Knock out (Mas-TRECK) male mice showed reduced social preference levels in a three-chamber sociability test without other behavioral changes, such as anxiety-like and depression-like behavior. Mas-TRECK male mice also had reduced serotonin content and serotonin receptor expression and increased oxytocin receptor expression in the brain. These results suggested that MCs may contribute to the regulation of social behavior in male mice. This effect may be partially mediated by serotonin derived from MCs in the brain. |
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キーワード | 推奨 | ||||
発行所 | 推奨 | ||||
誌名 | 必須 |
Behavioural Brain Research([Elsevier])
(pISSN: 0166-4328, eISSN: 1872-7549)
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巻 | 必須 | 403 | |||
号 | 必須 | --- | |||
頁 | 必須 | 113143 113143 | |||
都市 | 任意 | ||||
年月日 | 必須 | 2021年 1月 28日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.1016/j.bbr.2021.113143 (→Scopusで検索) | |||
PMID | 任意 | 33516739 (→Scopusで検索) | |||
CRID | 任意 | ||||
WOS | 任意 | ||||
Scopus | 任意 | ||||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
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