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著作: [福田 達也]/吉見 真太朗/[小暮 健太朗]/Leukocyte-mimetic liposomes penetrate into tumor spheroids and suppress spheroid growth by encapsulated doxorubicin/[Journal of Pharmaceutical Sciences]

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EID
373040
EOID
999043
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0
LastModified
2021年1月25日(月) 20:24:50
Operator
大家 隆弘
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Owner
小暮 健太朗
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨 研究
共著種別 推奨
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著者 必須
  1. 福田 達也
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    学籍番号 推奨
  2. (英) Yoshimi Shintaroh / (日) 吉見 真太朗 / (読) よしみ しんたろう
    役割 任意
    貢献度 任意
    学籍番号 推奨 ****
  3. 小暮 健太朗([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Leukocyte-mimetic liposomes penetrate into tumor spheroids and suppress spheroid growth by encapsulated doxorubicin

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(英) As leukocytes can penetrate into deep regions of a tumor mass, leukocyte-mimetic liposomes (LM-Lipo) containing leukocyte membrane proteins are also expected to penetrate into tumors by exerting properties of those membrane proteins. The aim of the present study was to examine whether LM-Lipo, which were recently demonstrated to actively pass through inflamed endothelial layers, can penetrate into tumor spheroids, and to investigate the potential of LM-Lipo for use as an anticancer drug carrier. We prepared LM-Lipo via intermembrane protein transfer from human leukemia cells; transfer of leukocyte membrane proteins onto the liposomes was determined by Western blotting. LM-Lipo demonstrated a significantly high association with human lung cancer A549 cells compared with plain liposomes, which contributed to effective anti-proliferative action by encapsulated doxorubicin hydrochloride (DOX). Confocal microscopic images showed that LM-Lipo, but not plain liposomes, could efficiently penetrate into A549 tumor spheroids. Moreover, DOX-encapsulated LM-Lipo significantly suppressed tumor spheroid growth. Thus, leukocyte membrane proteins transferred onto LM-Lipo retained their unique function, which allowed for efficient penetration of the liposomes into tumor spheroids, similar to leukocytes. In conclusion, these results suggest that LM-Lipo could be a useful tumor-penetrating drug delivery system for cancer treatment.

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誌名 必須 Journal of Pharmaceutical Sciences(American Pharmaceutical Association/American Pharmacists Association/Fédération internationale pharmaceutique/American Association of Pharmaceutical Scientists)
(pISSN: 0022-3549, eISSN: 1520-6017)
ISSN 任意 1520-6017
ISSN: 0022-3549 (pISSN: 0022-3549, eISSN: 1520-6017)
Title: Journal of pharmaceutical sciences
Title(ISO): J Pharm Sci
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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都市 任意
年月日 必須 2020年 12月 初日
URL 任意
DOI 任意 10.1016/j.xphs.2020.10.049    (→Scopusで検索)
PMID 任意 33129835    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-85096382956
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指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: S0022-3549(20)30665-1

  2. (英) Article.ELocationID: 10.1016/j.xphs.2020.10.049

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) KeywordList.Keyword: Cancer

  5. (英) KeywordList.Keyword: Intermembrane protein transfer

  6. (英) KeywordList.Keyword: Leukocyte

  7. (英) KeywordList.Keyword: Leukocyte-mimetic drug delivery system

  8. (英) KeywordList.Keyword: Liposome

  9. (英) KeywordList.Keyword: Tumor spheroid