著作: Tamura Takashi/Kuriyama Nagato/Koyama Teruhide/Ozaki Etsuko/Matsui Daisuke/Kadomatsu Yuka/Tsukamoto Mineko/Kubo Yoko/Okada Rieko/Hishida Asahi/Sasakabe Tae/Kawai Sayo/Naito Mariko/Takashima Naoyuki/Kadota Aya/Tanaka Keitaro/Hara Megumi/Suzuki Sadao/Nakagawa-Senda Hiroko/Takezaki Toshiro/Shimoshikiryo Ippei/Ikezaki Hiroaki/Murata Masayuki/Oze Isao/Ito Hidemi/Mikami Haruo/Nakamura Yohko/Kuriki Kiyonori/[有澤 孝吉]/Uemura Hirokazu/Takeuchi Kenji/Wakai Kenji/Association between plasma levels of homocysteine, folate, and vitamin B12, and dietary folate intake and hypertension in a cross-sectional study/[Scientific Reports]
(英) Association between plasma levels of homocysteine, folate, and vitamin B12, and dietary folate intake and hypertension in a cross-sectional study
(英) There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41-3.96) in men and 1.86 (95% CI 1.11-3.11) in women, as compared with the lowest group (P for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (P for trend = 0.099 and 0.703, respectively). Plasma vitamin B was positively associated with hypertension only in women (P for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B.
Scientific Reports([Nature Publishing Group])
|年月日||必須||2020年 10月 28日|