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著作: Sabit Ilhamjan/[橋本 登]/Matsumoto Yasuyuki/Yamaji Toshiyuki/Furukawa Keiko/Furukawa Koichi/Binding of a sialic acid-recognizing lectin Siglec-9 modulates adhesion dynamics of cancer cells via calpain-mediated protein degradation./[The Journal of Biological Chemistry]

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EID
370991
EOID
990938
Map
0
LastModified
2020年9月2日(水) 18:50:16
Operator
橋本 登
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橋本 登
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Sabit Ilhamjan
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 橋本 登([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Matsumoto Yasuyuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Yamaji Toshiyuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Furukawa Keiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Furukawa Koichi
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Binding of a sialic acid-recognizing lectin Siglec-9 modulates adhesion dynamics of cancer cells via calpain-mediated protein degradation.

副題 任意
要約 任意

(英) Although regulatory mechanisms for immune cells with inhibitory signals via immunoreceptor tyrosine-based inhibitory motifs are well known, signals transduced via interaction between Siglecs and sialyl compounds on their counterreceptors into target cells have not been reported to date. In this study, we found that an astrocytoma cell line, AS, showed detachment from culture plates when co-cultured with Siglec-9-expressing cells and/or soluble Siglec-9. Moreover, detached AS cells regrew as co-cultured cells with Siglec-9-deficient cells. They also showed increased motility and invasiveness upon Siglec-9 binding. In immunoblotting, rapid degradation of focal adhesion kinase (FAK) and related signaling molecules such as Akt, paxillin, and p130Cas was observed immediately after the co-culture. Despite degradation of these molecules, increased p-Akt was found at the front region of the cytoplasm, probably reflecting increased cell motility. Calpain was considered to be a responsible protease for the protein degradation by the inhibition experiments. These results suggest that protein degradation of FAK and related molecules was induced by Siglec-9 binding to its counterreceptors via sialylglycoconjugates, leading to the modulation of adhesion kinetics of cancer cells. Thus, this might be a mechanism by which cancer cells utilize Siglec-9-derived signals to escape from immunosurveillance.

キーワード 推奨
  1. (英) Antigens, CD
  2. (英) Calpain
  3. (英) Cell Adhesion
  4. (英) Cell Line, Tumor
  5. (英) Focal Adhesion Kinase 1
  6. (英) Humans
  7. (英) Neoplasm Proteins
  8. (英) Neoplasms
  9. (英) Protein Binding
  10. (英) Receptors, Mitogen
  11. (英) Sialic Acid Binding Immunoglobulin-like Lectins
  12. シグナル伝達(signal transduction)
  13. (英) U937 Cells
発行所 推奨
誌名 必須 The Journal of Biological Chemistry([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)
ISSN 任意 1083-351X
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 288
必須 49
必須 35417 35427
都市 任意
年月日 必須 2013年 10月 21日
URL 任意
DOI 任意 10.1074/jbc.M113.513192    (→Scopusで検索)
PMID 任意 24145038    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) PublicationType: Journal Article

  2. (英) PublicationType: Research Support, Non-U.S. Gov't