徳島大学 教育・研究者情報データベース(EDB)

1. 中川 貴之

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. 工藤 景子([徳島大学.病院.診療科.歯科口腔外科.口腔外科])

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. 福田 直志([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔外科学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. (英) Tachikawa Noriko

   役割	任意
   貢献度	任意
   学籍番号	推奨

5. (英) Koyano Kiyoshi

   役割	任意
   貢献度	任意
   学籍番号	推奨

6. (英) Matsushita Yasuyuki

   役割	任意
   貢献度	任意
   学籍番号	推奨

7. (英) Ishikawa Kunio / (日) 石川 邦夫

   役割	任意
   貢献度	任意
   学籍番号	推奨

8. 宮本 洋二

   役割	任意
   貢献度	任意
   学籍番号	推奨

(英) Application of low-crystalline carbonate apatite granules in 2-stage sinus floor augmentation: a prospective clinical trial and histomorphometric evaluation.

(英) The purpose of this study was to elucidate the efficacy and safety of carbonate apatite (COAp) granules in 2-stage sinus floor augmentation through the radiographic and histomorphometric assessment of bone biopsy specimens. Two-stage sinus floor augmentation was performed on 13 patients with a total of 17 implants. Radiographic assessment using panoramic radiographs was performed immediately after augmentation and was also performed 2 additional times, at 7±2 months and 18±2 months post-augmentation, respectively. Bone biopsy specimens taken from planned implant placement sites underwent micro-computed tomography, after which histological sections were prepared. Postoperative healing of the sinus floor augmentation was uneventful in all cases. The mean preoperative residual bone height was 3.5±1.3 mm, and this was increased to 13.3±1.7 mm by augmentation with the COAp granules. The mean height of the augmented site had decreased to 10.7±1.9 mm by 7±2 months after augmentation; however, implants with lengths in the range of 6.5 to 11.5 mm could still be placed. The mean height of the augmented site had decreased to 9.6±1.4 mm by 18±2 months post-augmentation. No implant failure or complications were observed. Few inflammatory cells or foreign body giant cells were observed in the bone biopsy specimens. Although there were individual differences in the amount of new bone detected, new bone was observed to be in direct contact with the COAp granules in all cases, without an intermediate layer of fibrous tissue. The amounts of bone and residual COAp were 33.8%±15.1% and 15.3%±11.9%, respectively. In this first demonstration, low-crystalline COAp granules showed excellent biocompatibility, and bone biopsy showed them to be replaced with bone in humans. COAp granules are a useful and safe bone substitute for two-stage sinus floor augmentation. ICTRP Identifier: JPRN-UMIN000019281.

1. (英) Article.ELocationID: 10.5051/jpis.2019.49.6.382

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) KeywordList.Keyword: Apatites

4. (英) KeywordList.Keyword: Dental implant

5. (英) KeywordList.Keyword: Sinus floor augmentation

6. (英) CoiStatement: Conflict of Interest: No potential conflict of interest relevant to this article was reported.