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著作: Shikama Yosuke/Kurosawa Mie/Furukawa Masae/[石丸 直澄]/Matsushita Kenji/Involvement of adiponectin in age-related increases in tear production in mice./[Aging]

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EID
368631
EOID
987349
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0
LastModified
2020年8月20日(木) 20:15:50
Operator
大家 隆弘
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TRUE
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Owner
石丸 直澄
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Shikama Yosuke
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Kurosawa Mie
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Furukawa Masae
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 石丸 直澄([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Matsushita Kenji
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Involvement of adiponectin in age-related increases in tear production in mice.

副題 任意
要約 任意

(英) Common age-related changes in the human eye contribute to the development of dry eye, including decreases in aqueous tear production. Although the infiltration of lymphocytes into the lacrimal glands occurs with age, age-related increases in tear production have also been observed in mice; however, the mechanisms underlying this increase remain unclear. We herein demonstrated that increases in tear production were not dependent on body weight gain or systemic conditions, such as insulin resistance, using aged mice and high-fat diet-fed mice. The results obtained also showed that senescence-associated T (SA-T) cells accumulated in the lacrimal glands of aged mice, particularly females. Expression levels of the nuclear transcription factor peroxisome proliferator-activated receptor-γ (PPARγ) in whole lacrimal glands and epithelial cells isolated from lacrimal glands were significantly higher in aged mice than in young mice. The expression levels of adiponectin and one of its receptors, AdipoR2, also increased in the lacrimal glands of aged mice, but not in those of high-fat diet-fed mice. Collectively, the present results indicate that PPARγ and adiponectin-mediated signaling contribute to age-related increases in tear production in mice and have potential as therapeutic targets for the treatment of dry eye in humans.

キーワード 推奨
発行所 推奨
誌名 必須 Aging(Impact Journals, LLC)
(eISSN: 1945-4589)
ISSN 任意 1945-4589
ISSN: 1945-4589 (eISSN: 1945-4589)
Title: Aging
Title(ISO): Aging (Albany NY)
Publisher: Impact Journals LLC
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 11
必須 19
必須 8329 8346
都市 任意
年月日 必須 2019年 10月 8日
URL 任意
DOI 任意 10.18632/aging.102322    (→Scopusで検索)
PMID 任意 31596727    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-85073646229
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.18632/aging.102322

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) KeywordList.Keyword: adiponectin

  5. (英) KeywordList.Keyword: aging

  6. (英) KeywordList.Keyword: dry eye

  7. (英) KeywordList.Keyword: peroxisome proliferator-activated receptor gamma

  8. (英) KeywordList.Keyword: senescence-associated T cells