徳島大学 教育・研究者情報データベース(EDB)

1. (英) Aadachi Seiko

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. (英) Hamoya Takahiro

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. (英) Fujii Gen

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. (英) Narita Takumi

   役割	任意
   貢献度	任意
   学籍番号	推奨

5. (英) Komiya Masami

   役割	任意
   貢献度	任意
   学籍番号	推奨

6. (英) Miyamoto Shingo

   役割	任意
   貢献度	任意
   学籍番号	推奨

7. (英) Kurokawa Yurie

   役割	任意
   貢献度	任意
   学籍番号	推奨

8. (英) Takahashi Maiko

   役割	任意
   貢献度	任意
   学籍番号	推奨

9. 高山 哲治([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

10. (英) ishikawa Hideki

    役割	任意
    貢献度	任意
    学籍番号	推奨

11. (英) Tashiro Kosuke

    役割	任意
    貢献度	任意
    学籍番号	推奨

12. (英) Mutoh Michihiro

    役割	任意
    貢献度	任意
    学籍番号	推奨

(英) Theracurmin inhibits intestinal polyp development in Apc-mutant mice by inhibiting inflammation-related factors.

(英) Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Therefore, it is important to establish useful methods for preventing CRC. One prevention strategy involves the use of cancer chemopreventive agents, including functional foods. We focused on the well-known cancer chemopreventive agent curcumin, which is derived from turmeric. However, curcumin has the disadvantage of being poorly soluble in water due to its high hydrophobicity. To overcome this problem, the formation of submicron particles with surface controlled technology has been applied to curcumin to give it remarkably improved water solubility, and this derived compound is named Theracurmin. To date, the preventive effects of Theracurmin on hereditary intestinal carcinogenesis have not been elucidated. Thus, we used Apc-mutant mice, a model of familial adenomatous polyposis, to evaluate the effects of Theracurmin. First, we showed that treatment with 10-20 µM Theracurmin for 24 hours reduced nuclear factor-κB (NF-κB) transcriptional activity in human colon cancer DLD-1 and HCT116 cells. However, treatment with curcumin mixed in water did not change the NF-κB promoter transcriptional activity. As NF-κB is a regulator of inflammation-related factors, we next investigated the downstream targets of NF-κB: monocyte chemoattractant protein-1 (MCP-1) and interleukin (IL)-6. We found that treatment with 500 ppm Theracurmin for 8 weeks inhibited intestinal polyp development and suppressed MCP-1 and IL-6 mRNA expression levels in the parts of the intestine with polyps. This report provides a proof of concept for the ongoing Theracurmin human trial (J-CAP-C study).

1. (英) Adenomatous Polyposis Coli
2. (英) Adenomatous Polyposis Coli Protein
3. (英) Animals
4. (英) Carcinogenesis
5. (英) Chemokine CCL2
6. (英) Colorectal Neoplasms
7. (英) Curcumin
8. (英) Disease Models, Animal
9. (英) Gene Expression Regulation, Neoplastic
10. (英) HCT116 Cells
11. (英) Humans
12. (英) Inflammation
13. (英) Interleukin-6
14. (英) Intestinal Polyps
15. (英) Intestines
16. (英) Mice
17. (英) NF-kappa B

1. (英) Article.ELocationID: 10.1111/cas.14329

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) KeywordList.Keyword: Theracurmin

4. (英) KeywordList.Keyword: colorectal cancer chemoprevention

5. (英) KeywordList.Keyword: curcumin

6. (英) KeywordList.Keyword: min mice

7. (英) KeywordList.Keyword: nuclear factor-κB