徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: 三好 雅士/井上 雄介/Nishioka Mai/[池亀 彰茂]/[中尾 隆之]/[岸 誠司]/[土井 俊夫]/[長井 幸二郎]/Clinical evaluation of presepsin considering renal function./[PLoS ONE]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
367928
EOID
991008
Map
0
LastModified
2020年9月2日(水) 19:46:10
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
長井 幸二郎
Read
継承
Write
継承
Delete
継承
種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Miyoshi Masashi / (日) 三好 雅士 / (読) みよし まさし
    役割 任意
    貢献度 任意
    学籍番号 推奨 ****
  2. (英) Inoue Yusuke / (日) 井上 雄介 / (読) いのうえ ゆうすけ
    役割 任意
    貢献度 任意
    学籍番号 推奨 ****
  3. (英) Nishioka Mai
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 池亀 彰茂
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 中尾 隆之
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 岸 誠司
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 土井 俊夫
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. 長井 幸二郎
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Clinical evaluation of presepsin considering renal function.

副題 任意
要約 任意

(英) Presepsin, a glycoprotein produced during bacterial phagocytosis, is used as a sepsis marker for bacterial infections. However, presepsin levels are affected by renal function, and the evaluation criteria according to kidney function or in chronic kidney diseases remain controversial. Furthermore, presepsin may be increased by sample stirring, but no studies have evaluated this effect.In this study, we excluded the effect of stirring by standardizing the blood collection conditions, analyzed the influence of kidney function on presepsin concentrations, and recalculated the reference range based on the findings. EDTA-whole blood from 47 healthy subjects and 85 patients with chronic kidney disease was collected to measure presepsin by PATHFAST. Presepsin was found to be significantly correlated with the levels of creatinine (r = 0.834), eGFRcreat (r = 0.837), cystatin-C (r = 0.845), and eGFRcys (r = 0.879). Furthermore, in patients with CKD, presepsin levels stratified by eGFRcys showed a significant increase in the CKD G2 patient group and with advancing glomerular filtration rate stage. The following values were obtained: Normal: 97.6 ± 27.4 pg/mL, CKD G1: 100.2 ± 27.6 pg/mL, CKD G2: 129.7 ± 40.7 pg/mL, CKD G3: 208.1 ± 70.2 pg/mL, CKD G4: 320.2 ± 170.1 pg/mL, CKD G5: 712.8 ± 336.3 pg/mL. The reference range, calculated by a nonparametric method using 67 cases of healthy volunteers and patients with chronic kidney disease G1, was found to be 59-153 pg/mL, which was notably lower than the standard reference range currently used. Presepsin concentrations were positively correlated with a few biomarkers of renal function, indicating the necessity to consider the effect of renal function in patients with renal impairment. Using the recalculated reference range considering kidney function may improve the accuracy of evaluating presepsin for diagnosis of sepsis compared to the standard reference currently in use.

キーワード 推奨
  1. (英) Adult
  2. (英) Aged
  3. (英) Biomarkers
  4. (英) Creatinine
  5. (英) Cystatins
  6. (英) Female
  7. (英) Glomerular Filtration Rate
  8. (英) Humans
  9. (英) Kidney
  10. (英) Lipopolysaccharide Receptors
  11. (英) Male
  12. (英) Middle Aged
  13. (英) Peptide Fragments
  14. (英) Renal Insufficiency, Chronic
発行所 推奨
誌名 必須 PLoS ONE(Public Library of Science)
(eISSN: 1932-6203)
ISSN 任意 1932-6203
ISSN: 1932-6203 (eISSN: 1932-6203)
Title: PloS one
Title(ISO): PLoS One
Publisher: PLOS
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 14
必須 9
必須 e0215791 e0215791
都市 任意
年月日 必須 2019年 9月 6日
URL 任意
DOI 任意 10.1371/journal.pone.0215791    (→Scopusで検索)
PMID 任意 31490935    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1371/journal.pone.0215791

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) CoiStatement: The authors have read the journal's policy and have the following conflicts: author Kojiro Nagai is a PLOS ONE Editional board member. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.