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著作: Kubota Kunitsugu/Mase Akihito/Matsushima Hiroaki/Fujitsuka Naoki/Yamamoto Masahiro/[森根 裕二]/Taketomi Akinobu/Kono Toru/[島田 光生]/Daikenchuto, a traditional Japanese herbal medicine, promotes colonic transit by inducing a propulsive movement pattern./[Neurogastroenterology and Motility]

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EID
367227
EOID
983252
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LastModified
2020年7月29日(水) 09:29:28
Operator
島田 光生
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島田 光生
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種別 必須
言語 必須 英語
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著者 必須
  1. (英) Kubota Kunitsugu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Mase Akihito
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Matsushima Hiroaki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Fujitsuka Naoki
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    貢献度 任意
    学籍番号 推奨
  5. (英) Yamamoto Masahiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 森根 裕二([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学]/[徳島大学.病院.診療科.外科.消化器・移植外科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Taketomi Akinobu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Kono Toru
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    学籍番号 推奨
  9. 島田 光生([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Daikenchuto, a traditional Japanese herbal medicine, promotes colonic transit by inducing a propulsive movement pattern.

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(英) The traditional Japanese herbal medicine, daikenchuto (DKT), has been used to treat constipation and postoperative ileus. However, the precise mechanisms involved in the pharmacological effects of DKT remain uncertain. The aim of this study was to clarify the effect of DKT on motor patterns and transit activity in the isolated rat colon. The entire colon or segments of the proximal colon in rats were isolated and placed in Krebs solution. The motility of the colon was evaluated by analyzing spatiotemporal maps of diameter derived from video imaging and measuring the intraluminal pressure in the anal end of the proximal colon, and the transit time of a plastic bead through the entire isolated colon. Several types of propagating contractions were observed in the isolated entire colon. When DKT was added to Krebs solution, the frequency of large-extent anal propagating contractions increased. DKT treatment increased the intraluminal pressure in the isolated proximal colon, which was related to the propagating contractions. This effect was abolished by treatment with the neural blocker tetrodotoxin. These findings suggest DKT induced peristaltic contractions in the isolated colon. DKT accelerated colonic transit activity, which was related to peristaltic contractions induction in the colon. These effects were also observed in the colons treated with bethanechol and the active ingredient of DKT, hydroxy- -sanshool. Daikenchuto could enhance colonic transit activity by inducing peristaltic contractions, which may be mediated by the activation of the enteric nervous system in the colon.

キーワード 推奨
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誌名 必須 Neurogastroenterology and Motility(European Gastrointestinal Motility Society/American Neurogastroenterology and Motility Society/Functional Brain-Gut Research Group)
(pISSN: 1350-1925, eISSN: 1365-2982)
ISSN 任意 1365-2982
ISSN: 1350-1925 (pISSN: 1350-1925, eISSN: 1365-2982)
Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
Title(ISO): Neurogastroenterol Motil
Supplier: European Society of Neurogastroenterology and Motility
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 31
必須 11
必須 e13689 e13689
都市 任意
年月日 必須 2019年 8月 2日
URL 任意
DOI 任意 10.1111/nmo.13689    (→Scopusで検索)
PMID 任意 31374154    (→Scopusで検索)
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Scopus 任意
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被引用数 任意
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  1. (英) Article.ELocationID: 10.1111/nmo.13689

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) KeywordList.Keyword: Colon

  5. (英) KeywordList.Keyword: daikenchuto

  6. (英) KeywordList.Keyword: hydroxy- -sanshool

  7. (英) KeywordList.Keyword: peristaltic contraction

  8. (英) KeywordList.Keyword: postoperative ileus