著作: [福田 達也]/大島 康史/道上 巧基/田中 太智/[小暮 健太朗]/Non-invasive delivery of biological macromolecular drugs into the skin by iontophoresis and its application to psoriasis treatment/[Journal of Controlled Release]
ヘルプを読む
「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)
- 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.
種別 | 必須 | 学術論文(審査論文) | |||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
言語 | 必須 | 英語 | |||||||||||||||||||||||||||||||||||||||||||||
招待 | 推奨 | ||||||||||||||||||||||||||||||||||||||||||||||
審査 | 推奨 | Peer Review | |||||||||||||||||||||||||||||||||||||||||||||
カテゴリ | 推奨 | ||||||||||||||||||||||||||||||||||||||||||||||
共著種別 | 推奨 | 学内共著(徳島大学内研究者との共同研究 (学外研究者を含まない)) | |||||||||||||||||||||||||||||||||||||||||||||
学究種別 | 推奨 | ||||||||||||||||||||||||||||||||||||||||||||||
組織 | 推奨 | ||||||||||||||||||||||||||||||||||||||||||||||
著者 | 必須 |
|
|||||||||||||||||||||||||||||||||||||||||||||
題名 | 必須 |
(英) Non-invasive delivery of biological macromolecular drugs into the skin by iontophoresis and its application to psoriasis treatment |
|||||||||||||||||||||||||||||||||||||||||||||
副題 | 任意 | ||||||||||||||||||||||||||||||||||||||||||||||
要約 | 任意 |
(英) Biological macromolecular drugs, such as antibodies and fusion protein drugs, have been widely employed for the treatment of various diseases. Administration routes are typically via invasive intravenous or subcutaneous injection with needles; the latter is challenging for applications involving inflamed skin (e.g., psoriasis) due to concerns of expansion of inflammation. As a method of non-invasive transdermal drug delivery, we previously demonstrated that iontophoresis (IP) using weak electric current (0.3-0.5 mA/cm) enables transdermal permeation of hydrophilic macromolecules, such as small interfering RNA and nanoparticles into the skin, and subsequent exertion of their functions. The underlying mechanism was revealed to be via intercellular junction cleavage by cellular signaling activation initiated by Ca influx. Based on these findings, in the present study, we hypothesized that non-invasive intradermal delivery of biological macromolecular drugs could be efficiently achieved via IP. Fluorescence of FITC-labeled IgG antibody was broadly observed in the skin after IP administration (0.4 mA/cm for 1 h) and extended from the epidermis to the dermis layer of hairless rats; passive antibody diffusion was not observed. In imiquimod-induced psoriasis model rats, antibodies were also delivered via IP into inflamed skin tissue. Additionally, upregulation of interleukin-6 mRNA levels, which is related to pathological progression of psoriasis, was significantly inhibited by IP of the anti-tumor necrosis factor-α drug etanercept, but not by its subcutaneous injection. Importantly, IP administration of etanercept significantly ameliorated epidermis hyperplasia, a symptom of psoriasis. Taken together, the present study is the first to demonstrate that IP can be applied as a non-invasive and efficient intradermal drug delivery technology for biological macromolecular drugs. |
|||||||||||||||||||||||||||||||||||||||||||||
キーワード | 推奨 | ||||||||||||||||||||||||||||||||||||||||||||||
発行所 | 推奨 | ||||||||||||||||||||||||||||||||||||||||||||||
誌名 | 必須 |
Journal of Controlled Release(Controlled Release Society)
(pISSN: 0168-3659, eISSN: 1873-4995)
|
|||||||||||||||||||||||||||||||||||||||||||||
巻 | 必須 | 323 | |||||||||||||||||||||||||||||||||||||||||||||
号 | 必須 | --- | |||||||||||||||||||||||||||||||||||||||||||||
頁 | 必須 | 323 332 | |||||||||||||||||||||||||||||||||||||||||||||
都市 | 任意 | ||||||||||||||||||||||||||||||||||||||||||||||
年月日 | 必須 | 2020年 4月 28日 | |||||||||||||||||||||||||||||||||||||||||||||
URL | 任意 | ||||||||||||||||||||||||||||||||||||||||||||||
DOI | 任意 | 10.1016/j.jconrel.2020.04.044 (→Scopusで検索) | |||||||||||||||||||||||||||||||||||||||||||||
PMID | 任意 | 32360305 (→Scopusで検索) | |||||||||||||||||||||||||||||||||||||||||||||
CRID | 任意 | ||||||||||||||||||||||||||||||||||||||||||||||
WOS | 任意 | ||||||||||||||||||||||||||||||||||||||||||||||
Scopus | 任意 | 2-s2.0-85084069379 | |||||||||||||||||||||||||||||||||||||||||||||
評価値 | 任意 | ||||||||||||||||||||||||||||||||||||||||||||||
被引用数 | 任意 | ||||||||||||||||||||||||||||||||||||||||||||||
指導教員 | 推奨 | ||||||||||||||||||||||||||||||||||||||||||||||
備考 | 任意 |
|