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著作: [福田 達也]/大島 康史/道上 巧基/田中 太智/[小暮 健太朗]/Non-invasive delivery of biological macromolecular drugs into the skin by iontophoresis and its application to psoriasis treatment/[Journal of Controlled Release]

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EID
365844
EOID
983647
Map
0
LastModified
2020年7月31日(金) 14:22:37
Operator
大家 隆弘
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TRUE
Censor
0
Owner
小暮 健太朗
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨 学内共著(徳島大学内研究者との共同研究 (学外研究者を含まない))
学究種別 推奨
組織 推奨
著者 必須
  1. 福田 達也([徳島大学.大学院医歯薬学研究部.薬学域.先端薬学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Oshima Yasufumi / (日) 大島 康史 / (読) おおしま やすふみ
    役割 任意
    貢献度 任意
    学籍番号 推奨 ****
  3. (英) Michiue Kohki / (日) 道上 巧基 / (読) みちうえ こうき
    役割 任意
    貢献度 任意
    学籍番号 推奨 ****
  4. (英) Tanaka Daichi / (日) 田中 太智 / (読) たなか だいち
    役割 任意
    貢献度 任意
    学籍番号 推奨 ****
  5. 小暮 健太朗([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Non-invasive delivery of biological macromolecular drugs into the skin by iontophoresis and its application to psoriasis treatment

副題 任意
要約 任意

(英) Biological macromolecular drugs, such as antibodies and fusion protein drugs, have been widely employed for the treatment of various diseases. Administration routes are typically via invasive intravenous or subcutaneous injection with needles; the latter is challenging for applications involving inflamed skin (e.g., psoriasis) due to concerns of expansion of inflammation. As a method of non-invasive transdermal drug delivery, we previously demonstrated that iontophoresis (IP) using weak electric current (0.3-0.5 mA/cm) enables transdermal permeation of hydrophilic macromolecules, such as small interfering RNA and nanoparticles into the skin, and subsequent exertion of their functions. The underlying mechanism was revealed to be via intercellular junction cleavage by cellular signaling activation initiated by Ca influx. Based on these findings, in the present study, we hypothesized that non-invasive intradermal delivery of biological macromolecular drugs could be efficiently achieved via IP. Fluorescence of FITC-labeled IgG antibody was broadly observed in the skin after IP administration (0.4 mA/cm for 1 h) and extended from the epidermis to the dermis layer of hairless rats; passive antibody diffusion was not observed. In imiquimod-induced psoriasis model rats, antibodies were also delivered via IP into inflamed skin tissue. Additionally, upregulation of interleukin-6 mRNA levels, which is related to pathological progression of psoriasis, was significantly inhibited by IP of the anti-tumor necrosis factor-α drug etanercept, but not by its subcutaneous injection. Importantly, IP administration of etanercept significantly ameliorated epidermis hyperplasia, a symptom of psoriasis. Taken together, the present study is the first to demonstrate that IP can be applied as a non-invasive and efficient intradermal drug delivery technology for biological macromolecular drugs.

キーワード 推奨
発行所 推奨
誌名 必須 Journal of Controlled Release(Controlled Release Society)
(pISSN: 0168-3659, eISSN: 1873-4995)
ISSN 任意 1873-4995
ISSN: 0168-3659 (pISSN: 0168-3659, eISSN: 1873-4995)
Title: Journal of controlled release : official journal of the Controlled Release Society
Title(ISO): J Control Release
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 323
必須 ---
必須 323 332
都市 任意
年月日 必須 2020年 4月 28日
URL 任意
DOI 任意 10.1016/j.jconrel.2020.04.044    (→Scopusで検索)
PMID 任意 32360305    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-85084069379
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: S0168-3659(20)30258-3

  2. (英) Article.ELocationID: 10.1016/j.jconrel.2020.04.044

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) KeywordList.Keyword: Antibody

  5. (英) KeywordList.Keyword: Biological macromolecular drugs

  6. (英) KeywordList.Keyword: Inflammation

  7. (英) KeywordList.Keyword: Iontophoresis

  8. (英) KeywordList.Keyword: Psoriasis

  9. (英) KeywordList.Keyword: Transdermal drug delivery

  10. (英) CoiStatement: Declaration of Competing Interest The authors declare no competing financial interests.