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著作: Tsujii N/Otsuka I/Okazaki S/Yanagi M/[沼田 周助]/Yamaki N/Kawakubo Y/Shirakawa O/Hishimoto A/Mitochondrial DNA Copy Number Raises the Potential of Left Frontopolar Hemodynamic Response as a Diagnostic Marker for Distinguishing Bipolar Disorder From Major Depressive Disorder./[Frontiers in Psychiatry]

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EID
365491
EOID
1060548
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0
LastModified
2022年10月17日(月) 11:58:33
Operator
大家 隆弘
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TRUE
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Owner
沼田 周助
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨 国内共著(徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Tsujii N
    役割 任意
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    学籍番号 推奨
  2. (英) Otsuka I
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  3. (英) Okazaki S
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  4. (英) Yanagi M
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  5. 沼田 周助([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.精神医学]/[徳島大学.病院.診療科.脳·神経·精神科.精神科神経科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Yamaki N
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    貢献度 任意
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  7. (英) Kawakubo Y
    役割 任意
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    学籍番号 推奨
  8. (英) Shirakawa O
    役割 任意
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  9. (英) Hishimoto A
    役割 任意
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    学籍番号 推奨
題名 必須

(英) Mitochondrial DNA Copy Number Raises the Potential of Left Frontopolar Hemodynamic Response as a Diagnostic Marker for Distinguishing Bipolar Disorder From Major Depressive Disorder.

副題 任意
要約 任意

(英) Given a lack of markers, diagnoses of bipolar disorder (BD) and major depressive disorder (MDD) rely on clinical assessment of symptoms. However, the depressive mood states of BD and depressive symptoms of MDD are often difficult to distinguish, which leads to misdiagnoses, which in turn leads to inadequate treatment. Previous studies have shown that the hemodynamic responses of the left frontopolar cortex measured by near-infrared spectroscopy (NIRS) differ between BD and MDD; these hemodynamic responses are associated with altered mitochondrial metabolism; and mitochondrial DNA copy number (mtDNAcn), an index of mitochondrial dysfunction, tends to decrease in BD and increase in MDD patients. In this study, we confirmed that mtDNAcn trends in opposite directions in BD and MDD. We then determined whether mtDNAcn could enhance the utility of NIRS as a diagnostic marker to distinguish between BD and MDD. We determined mtDNAcn in peripheral blood samples from 58 healthy controls, 79 patients with BD, and 44 patients with MDD. Regional hemodynamic responses during a verbal fluency task (VFT) in 24 BD patients and 44 MDD patients, matched by age and depression severity, were monitored using NIRS. Measurements of mtDNAcn were lower in BD patients and higher in MDD patients than in controls. The left frontopolar region exhibited the most significant differences in mean VFT-related oxy-Hb changes between the BD and MDD groups. Multivariate logistic regression analysis with variables including age, sex, hemodynamic response of the left frontopolar region, and mtDNAcn showed high accuracy for distinguishing BD from MDD (area under the curve = 0.917; 95% confidence interval = 0.849-0.985). For the BD group, we observed a positive correlation between hemodynamic responses in the left frontopolar region and mtDNAcn, while for the MDD group, we observed a negative correlation. Our findings suggest that the association between hemodynamic response and mitochondrial dysfunction in BD or MDD plays an important role in differentiating the pathophysiological mechanisms of BD from those of MDD.

キーワード 推奨
  1. (英) bipolar disorder
  2. (英) major depressive disorder
  3. (英) hemodynamics
  4. (英) mitochondria
  5. (英) near-infrared spectroscopy
発行所 推奨 (英) Frontiers Media
誌名 必須 Frontiers in Psychiatry(Frontiers Research Foundation)
(eISSN: 1664-0640)
ISSN 任意 1664-0640
ISSN: 1664-0640 (eISSN: 1664-0640)
Title: Frontiers in psychiatry
Title(ISO): Front Psychiatry
Publisher: Frontiers Media SA
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 10
必須 ---
必須 312 312
都市 任意
年月日 必須 2019年 5月 8日
URL 任意 http://www.lib.kobe-u.ac.jp/handle_kernel/90006004
DOI 任意 10.3389/fpsyt.2019.00312    (→Scopusで検索)
PMID 任意
CRID 任意 1360568619385026688
WOS 任意
Scopus 任意 2-s2.0-85068134991
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.3389/fpsyt.2019.00312

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) KeywordList.Keyword: bipolar disorder

  4. (英) KeywordList.Keyword: hemodynamics

  5. (英) KeywordList.Keyword: major depressive disorder

  6. (英) KeywordList.Keyword: mitochondria

  7. (英) KeywordList.Keyword: near-infrared spectroscopy