365487: Otsuka I/Akiyama M/Shirakawa O/Okazaki S/Momozawa Y/Kamatani Y/Izumi T/[沼田周助]/Takahashi M/Boku S/Sora I/Yamamoto K/Ueno Y/Toda T/Kubo M/Hishimoto A/Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population./[Neuropsychopharmacology]

著作: Otsuka I/Akiyama M/Shirakawa O/Okazaki S/Momozawa Y/Kamatani Y/Izumi T/[沼田周助]/Takahashi M/Boku S/Sora I/Yamamoto K/Ueno Y/Toda T/Kubo M/Hishimoto A/Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population./[Neuropsychopharmacology]

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EID: 365487
EOID: 1060415
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LastModified: 2022年10月13日(木) 21:08:35
Operator: 大家隆弘
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Owner: 沼田周助
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

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カテゴリ

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共著種別

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国内共著(徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))

学究種別

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組織

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著者

必須

(英) Otsuka I

役割任意

貢献度任意

学籍番号推奨
(英) Akiyama M

役割任意

貢献度任意

学籍番号推奨
(英) Shirakawa O

役割任意

貢献度任意

学籍番号推奨
(英) Okazaki S

役割任意

貢献度任意

学籍番号推奨
(英) Momozawa Y

役割任意

貢献度任意

学籍番号推奨
(英) Kamatani Y

役割任意

貢献度任意

学籍番号推奨
(英) Izumi T

役割任意

貢献度任意

学籍番号推奨
沼田周助([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.精神医学]/[徳島大学.病院.診療科.脳·神経·精神科.精神科神経科])

役割任意

貢献度任意

学籍番号推奨
(英) Takahashi M

役割任意

貢献度任意

学籍番号推奨
(英) Boku S

役割任意

貢献度任意

学籍番号推奨
(英) Sora I

役割任意

貢献度任意

学籍番号推奨
(英) Yamamoto K

役割任意

貢献度任意

学籍番号推奨
(英) Ueno Y

役割任意

貢献度任意

学籍番号推奨
(英) Toda T

役割任意

貢献度任意

学籍番号推奨
(英) Kubo M

役割任意

貢献度任意

学籍番号推奨
(英) Hishimoto A

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population.

副題

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要約

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(英) Suicide is a significant public health problem worldwide, and several Asian countries including Japan have relatively high suicide rates on a world scale. Twin, family, and adoption studies have suggested high heritability for suicide, but genetics lags behind due to difficulty in obtaining samples from individuals who died by suicide, especially in non-European populations. In this study, we carried out genome-wide association studies combining two independent datasets totaling 746 suicides and 14,049 non-suicide controls in the Japanese population. Although we identified no genome-wide significant single-nucleotide polymorphisms (SNPs), we demonstrated significant SNP-based heritability (35-48%; P < 0.001) for completed suicide by genomic restricted maximum-likelihood analysis and a shared genetic risk between two datasets (P = 2.7 × 10) by polygenic risk score analysis. This study is the first genome-wide association study for suicidal behavior in an East Asian population, and our results provided the evidence of polygenic architecture underlying completed suicide.

キーワード

推奨

(英) Age Factors
(英) Asian Continental Ancestry Group
(英) Female
(英) Genome-Wide Association Study
(英) Humans
(英) Japan
(英) Male
(英) Multifactorial Inheritance
(英) Polymorphism, Single Nucleotide
(英) Self-Injurious Behavior
(英) Suicide, Completed

発行所

推奨

(英) Nature Research

誌名

必須

Neuropsychopharmacology(American College of Neuropsychopharmacology)

(pISSN: 0893-133X, eISSN: 1740-634X)

ISSN	任意	1740-634X ISSN: 0893-133X (pISSN: 0893-133X, eISSN: 1740-634X) Title: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Title(ISO): Neuropsychopharmacology Publisher: Springer Nature (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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2119 2124

都市

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年月日

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2019年 11月初日

URL

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http://www.lib.kobe-u.ac.jp/handle_kernel/90006450

DOI

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10.1038/s41386-019-0506-5 (→Scopusで検索)

PMID

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31476763 (→Scopusで検索)

CRID

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1360568468295320704

WOS

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Scopus

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2-s2.0-85073313471

評価値

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被引用数

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指導教員

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備考

任意

(英) Article.ELocationID: 10.1038/s41386-019-0506-5
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

著作: Otsuka I/Akiyama M/Shirakawa O/Okazaki S/Momozawa Y/Kamatani Y/Izumi T/[沼田周助]/Takahashi M/Boku S/Sora I/Yamamoto K/Ueno Y/Toda T/Kubo M/Hishimoto A/Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population./[Neuropsychopharmacology]

著作: Otsuka I/Akiyama M/Shirakawa O/Okazaki S/Momozawa Y/Kamatani Y/Izumi T/[沼田 周助]/Takahashi M/Boku S/Sora I/Yamamoto K/Ueno Y/Toda T/Kubo M/Hishimoto A/Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population./[Neuropsychopharmacology]

著作: Otsuka I/Akiyama M/Shirakawa O/Okazaki S/Momozawa Y/Kamatani Y/Izumi T/[沼田周助]/Takahashi M/Boku S/Sora I/Yamamoto K/Ueno Y/Toda T/Kubo M/Hishimoto A/Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population./[Neuropsychopharmacology]