徳島大学 教育・研究者情報データベース(EDB)

1. (英) MATSUBARA Tomoko / (日) MATSUBARA Tomoko

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2. (英) ZEMPO-MIYAKI Asako / (日) ZEMPO-MIYAKI Asako

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3. (英) AKAZAWA Nobuhiko / (日) AKAZAWA Nobuhiko

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4. (英) CHOI Youngju

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5. 羅 成圭([徳島大学.教養教育院])

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6. (英) TANAHASHI Koichiro

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7. (英) KUMAGAI Hiroshi

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8. (英) OIKAWA Satoshi

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9. (英) YOSHIKAWA Toru

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10. (英) MAEDA Seiji

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(英) Aerobic Exercise Training Improves Vascular Endothelial Function with an Increase in Circulating Klotho Levels in Postmenopausal Women

(英) Circulating Klotho is expected to have vascular protective effects, including the enhancement of nitric oxide (NO) production by endothelial cells. Aerobic exercise training increases circulating Klotho levels and improves endothelial function, which decreases with aging. However, it is unclear whether aerobic exercise training-induced improvement in endothelial function is related to elevation of circulating Klotho levels. In the present study, we investigated the effect of aerobic exercise training on the correlation between plasma Klotho levels and endothelial function in postmenopausal women. First, we studied the correlation between plasma Klotho levels and flow-mediated vasodilation (FMD) as an index of endothelial function. FMD correlated positively with plasma Klotho levels, but the baseline diameter did not correlate with plasma Klotho levels. Second, we examined the effects of aerobic exercise training on plasma Klotho levels and FMD. After aerobic exercise training, plasma Klotho levels and FMD increased significantly. Furthermore, there was a positive correlation between the changes in plasma Klotho levels and those in FMD. These results suggested that an increase in circulating Klotho levels induced by aerobic exercise training may contribute to improvement of endothelial function.