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著作: [平田 章]/Recent Insights Into the Structure, Function, and Evolution of the RNA-Splicing Endonucleases./[Frontiers in Genetics]

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365323
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978026
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2020年4月16日(木) 15:59:50
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三好 小文
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平田 章
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種別 必須 総説·解説
言語 必須 英語
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  1. 平田 章([徳島大学.大学院社会産業理工学研究部.理工学域.自然科学系.生物科学分野])
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(英) Recent Insights Into the Structure, Function, and Evolution of the RNA-Splicing Endonucleases.

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(英) RNA-splicing endonuclease (EndA) cleaves out introns from archaeal and eukaryotic precursor (pre)-tRNA and is essential for tRNA maturation. In archaeal EndA, the molecular mechanisms underlying complex assembly, substrate recognition, and catalysis have been well understood. Recently, certain studies have reported novel findings including the identification of new subunit types in archaeal EndA structures, providing insights into the mechanism underlying broad substrate specificity. Further, metagenomics analyses have enabled the acquisition of numerous DNA sequences of EndAs and intron-containing pre-tRNAs from various species, providing information regarding the co-evolution of substrate specificity of archaeal EndAs and tRNA genetic diversity, and the evolutionary pathway of archaeal and eukaryotic EndAs. Although the complex structure of the heterothermic form of eukaryotic EndAs is unknown, previous reports regarding their functions indicated that mutations in human EndA cause neurological disorders including pontocerebellar hypoplasia and progressive microcephaly, and yeast EndA significantly cleaves mitochondria-localized mRNA encoding cytochrome b mRNA processing 1 (Cpb1) for mRNA maturation. This mini-review summarizes the aforementioned results, discusses their implications, and offers my personal opinion regarding future directions for the analysis of the structure and function of EndAs.

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誌名 必須 Frontiers in Genetics(Frontiers Research Foundation)
(eISSN: 1664-8021)
ISSN 任意 1664-8021
ISSN: 1664-8021 (eISSN: 1664-8021)
Title: Frontiers in genetics
Title(ISO): Front Genet
Publisher: Frontiers Media S.A.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 10
必須
必須 103 103
都市 任意
年月日 必須 2019年 2月 12日
URL 任意
DOI 任意 10.3389/fgene.2019.00103    (→Scopusで検索)
PMID 任意 30809252    (→Scopusで検索)
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Scopus 任意 2-s2.0-85065960491
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  1. (英) Article.ELocationID: 10.3389/fgene.2019.00103

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Review

  4. (英) KeywordList.Keyword: RNA-splicing endonuclease

  5. (英) KeywordList.Keyword: archaea and eukaryote

  6. (英) KeywordList.Keyword: broad substrate specificity

  7. (英) KeywordList.Keyword: co-evolution of protein and RNA

  8. (英) KeywordList.Keyword: intron-containing tRNA