徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.大学院社会産業理工学研究部(2017年4月1日〜)

1. 松木 均([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命コース])

   役割	任意	(日) 記述，考察
   貢献度	任意
   学籍番号	推奨

(英) Thermodynamic Study on Phase Transitions of Phospholipid Bilayer Membranes

(日) リン脂質二重膜相転移の熱力学的研究

(英) Phospholipid bilayer membranes undergo structural changes called phase transitions in response to various external environmental factors. They exhibit markedly complicated phase behavior due to the nonhomogeneous structures. We have investigated the bilayer phase transitions of various phospholipids with different molecular structures to elucidate the environmental adaptation of biological membranes. The constructed thermodynamic phase diagrams of the phospholipid bilayer membranes have revealed the correlation between the lipid molecular structures and the thermotropic and barotropic bilayer phase behavior. In this review, several types of bilayer phase behavior of representative glycerophospholipids contained in biological membranes, saturated diacyl-posphatidylcholines (PCs), -phosphatidylethanolamines (PEs) and -phosphatidylglycerols (PGs), are explained, and subsequently our lipid membrane studies based on the bilayer phase diagrams, formation of nonbilayer phases (chain interdigitation for saturated diacyl-PCs and inverted hexagonal transformation for unsaturated diacyl-PEs) and fluorescence imaging of bilayer packing for saturated diacyl-PCs, are introduced.

1. (英) calorimetry
2. (英) fluorescence imaging
3. 高圧力(high pressure)
4. (英) phospholipid bilayer membrane
5. 相図(phase diagram/->キーワード[相平衡])
6. 相転移(phase transition)