徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学(2004年4月1日〜)
2. 徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学(2015年4月1日〜)
3. 徳島大学.先端酵素学研究所.プロテオゲノム研究領域(2016年4月1日〜2020年3月31日)

1. 市原 亜起([徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])

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2. 泰江 章博

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3. ミツイ アカギ シルビア ナオミ

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4. 荒井 大志([徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])

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5. 峯岸 克行([徳島大学.先端酵素学研究所.重点研究部門])

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6. 親泊 政一([徳島大学.先端酵素学研究所.重点研究部門])

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7. 井本 逸勢

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8. 田中 栄二([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])

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(英) The C-terminal region including the MH6 domain of Msx1 regulates skeletal development.

(英) MSX1 is a causative gene for oligodontia in humans. Although conventional Msx1-deficient mice die neonatally, a mutant mouse lacking the C-terminus MH6 domain of MSX1 (Msx1) showed two different phenotypes; newborn homozygotes with cleft palates died neonatally, whereas those with thin palates remained alive and had craniofacial dysplasia and growth retardation compared with wild-type mice, with most mice dying by the age of 4-5 weeks. In a previously reported case of human oligodontia caused by a heterozygous defect of the Msx1 MH6 domain, a small foramen was observed on the occipital bone. The aim of this study was to test the hypothesis that the Msx1 MH6 domain is involved in bone formation in vivo. In Msx1 mice, cranial suture fusion was delayed at embryonic day 18.5, and the anteroposterior cranial diameter was smaller and long bone length was decreased at 3 weeks of age. The femoral epiphysis showed no change in the trabecular number, but decreased bone mass, bone density, and trabecular width in Msx1 mice. In addition, cancellous bone mass was reduced and the cartilage layer in the growth plate was thinner in Msx1 mice. The mRNA expression levels of major osteoblast and chondrocyte differentiation marker genes were decreased in Msx1 mice compared with wild-type mice. These findings suggest that the C-terminal region including the MH6 domain of MSX1 plays important roles not only in tooth development and palatal fusion, but also in postnatal bone formation.

1. (英) 3. Ichihara A, Yasue A, Mitsui SN, Arai D, Minegishi Y, Oyadomari S, Imoto I, Tanaka E. The C-terminal region including the MH6 domain of Msx1 regulates skeletal development. BBRC, in press.