徳島大学 教育・研究者情報データベース(EDB)

1. (英) Kondoh Yoshitsugu

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2. 近久 幸子

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3. 志内 哲也([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.生理学])

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4. 清水 紀之([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.顕微解剖学])

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5. (英) Tanioka Daisuke / (日) 谷岡 大輔 / (読) たにおか だいすけ

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6. (英) Uguisu Haruo / (日) 鶯 春夫 / (読) うぐいす はるお

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7. 勢井 宏義([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.生理学])

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(英) Sleep profile during fasting in PPAR-alpha knockout mice.

(英) Peroxisome proliferator-activated receptor alpha (PPARα) is a transcription factor that belongs to the nuclear receptor family and plays an important role in regulating gene expression associated with lipid metabolism. PPARα promotes hepatic fatty acid oxidation and ketogenesis in response to fasting. Because energy metabolism is known to affect sleep regulation, manipulations that change PPARα are likely to affect sleep and other physiological phenotypes. In this study, we examined the role of PPARα in sleep/wake regulation using PPARα knockout (KO) mice. Sleep, body temperature (BT), locomotor activity, arterial pressure (AP) and heart rate (HR) were recorded in KO mice and wild-type (WT) controls under ad libitum-fed conditions and 24-hour food deprivation (FD). KO and WT mice were identical in basal sleep amount, BT, mean AP and HR, although KO mice showed enhanced sleepiness (enhanced EEG slow-wave activity). In response to FD, KO mice showed a large drop in wakefulness and locomotor activity at the end of the dark phase, whereas WT mice did not. Similarly, AP and HR, which were suppressed by FD, decreased more in KO than in WT mice. Compared to WT mice, KO mice showed a reduced concentration of plasma ketone bodies and decreased mRNA expression of the ketogenic enzyme gene Hmgcs2 in the liver and brain under FD conditions. These results suggest that PPARα and/or lipid metabolism is involved in the maintenance of wakefulness and locomotor activity during fasting in mice.

1. (英) PublicationType: Journal Article