徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: [青田 桂子]/[可児 耕一]/[山ノ井 朋子]/[桃田 幸弘]/[二宮 雅美]/[湯本 浩通]/[東 雅之]/Management of tooth extraction in a patient with ELANE gene mutation-induced cyclic neutropenia: A case report./[Medicine]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
361137
EOID
967416
Map
0
LastModified
2019年12月4日(水) 13:44:12
Operator
三木 ちひろ
Avail
TRUE
Censor
0
Owner
青田 桂子
Read
継承
Write
継承
Delete
継承
種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 青田 桂子([徳島大学.病院.診療科.歯科口腔外科.口腔内科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 可児 耕一([徳島大学.病院.診療科.歯科口腔外科.口腔内科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 山ノ井 朋子
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 桃田 幸弘([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔内科学]/[徳島大学.病院.診療科.歯科口腔外科.口腔内科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 二宮 雅美([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 湯本 浩通([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 東 雅之
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Management of tooth extraction in a patient with ELANE gene mutation-induced cyclic neutropenia: A case report.

副題 任意
要約 任意

(英) Cyclic neutropenia (CyN) is a rare hematological disease, and patients with CyN often experience an early onset of severe periodontitis and are forced to undergo tooth extraction. Here, we report a case of a patient with CyN who showed different periodicity and oscillations of neutrophil count compared with her mother, despite sharing the same novel genetic mutation. A 17-year-old Japanese girl who had been diagnosed with CyN shortly after birth presented to our hospital with a complaint of mobility of her teeth and gingivitis. Upon presentation, an intraoral examination was performed and revealed redness and swelling of the marginal and attached gingiva. Radiographs revealed extreme resorption of the alveolar bone and apical lesions in her mandibular lateral incisors. The patient's hematologic data demonstrated a lack of blood neutrophils (0/μL). The patient had no history of dental extraction, and her mother also had a history of CyN. The patient was diagnosed with severe periodontitis that was associated with CyN. Gene testing showed a novel heterozygous mutation in exon 4 of the ELANE gene (c.538delC, p.Leu180Ser fsX11). Based on the clinical findings, we planned to extract the patient's mandibular lateral incisors. Although the tooth extraction was scheduled considering the cyclic variation in neutrophil count, the patient's neutrophil count was 0/μL on the day before the planned extraction. Therefore, granulocyte-colony stimulating factor (G-CSF) was administered to increase the patient's neutrophil count. On the day of the patient's admission for the tooth extraction, she presented with fever (body temperature, 38.5°C), tonsillitis, and stomatitis. The extraction was subsequently delayed, and the patient was administered antibiotics and G-CSF for 4 days. At this time, the neutrophil count increased to 750/μL, and the tooth extraction was carried out safely. The postoperative course was uneventful, and the healing process at the extraction site was excellent. There is a possibility that the periodicity and oscillations of neutrophil count may change with growth in patients with CyN. Therefore, it is important to frequently examine and treat patients with fluctuating neutrophil levels for the management of invasive dental treatment in patients with CyN.

キーワード 推奨
  1. (英) Adolescent
  2. (英) Exons
  3. 女性(female)
  4. (英) Humans
  5. (英) Leukocyte Count
  6. (英) Leukocyte Elastase
  7. (英) Mutation
  8. (英) Neutropenia
  9. (英) Neutrophils
  10. 歯周病(periodontitis)
  11. (英) Tooth Extraction
発行所 推奨
誌名 必須 Medicine([Lippincott Williams & Wilkins])
(pISSN: 0025-7974, eISSN: 1536-5964)
ISSN 任意 1536-5964
ISSN: 0025-7974 (pISSN: 0025-7974, eISSN: 1536-5964)
Title: Medicine
Title(ISO): Medicine (Baltimore)
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 98
必須 39
必須 e17372 e17372
都市 任意
年月日 必須 2019年 9月 初日
URL 任意
DOI 任意 10.1097/MD.0000000000017372    (→Scopusで検索)
PMID 任意 31574885    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-85072847226
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1097/MD.0000000000017372

  2. (英) Article.PublicationTypeList.PublicationType: Case Reports

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) SupplMeshList.SupplMeshName: Cyclic neutropenia