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著作: [山下 理子]/[佐野 壽昭]/[銭 志栄]/Kovacs Kalman/Horvath Eva/Diversity of ACTH-immunoreactive cells in the human adenohypophysis: an immunohistochemical study with special reference to cluster formation and follicular cell association./[Endocrine Pathology]

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EID
360415
EOID
965300
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2019年10月18日(金) 14:49:20
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山下 理子
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山下 理子
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
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組織 推奨
著者 必須
  1. 山下 理子([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.病理解析学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 佐野 壽昭
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 銭 志栄
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Kovacs Kalman
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Horvath Eva
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Diversity of ACTH-immunoreactive cells in the human adenohypophysis: an immunohistochemical study with special reference to cluster formation and follicular cell association.

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(英) Horvath et al. called relatively small ACTH-immunoreactive (ACTH-IR) cells observed in basophil invasion "proopiomelanocortin (POMC) cells," and these cells were supposed to be different from larger ACTH-IR cells in human adenohypophysis. To clarify the existence of "anterior POMC cells," we examined 21 autopsy cases taking note of follicular cells (FCs). We found that smaller ACTH-IR cells were clustered forming small areas without FC association, clustered small cell island (CSCI). CSCI was found in all the specimens we examined using immunohistochemical staining for ACTH and cytokeratin (AE1/AE3) in serial sections. ACTH-IR cells outside CSCI were of various sizes, mainly consisting of larger ACTH-IR cells that were diffusely scattered among other hormone-secreting cells and closely associated with FCs. By immunohistochemistry, ACTH-IR cells within CSCI and basophil invasion showed uniformly weak reactivity and common patterns for cytokeratins (CAM5.2 and 35 beta H11), carboxypeptidase D, and LeuM1, whereas those outside CSCI showed a great variety of immunoreactivity. The similarity in the immunoreactivity of ACTH-IR cells between CSCI and basophil invasion suggests that ACTH-IR cells in these two areas have common characteristics and ACTH-IR cells in CSCI are most likely "POMC cells." The clustered "anterior POMC cells" may be distinguishable by light microscopic immunohistochemistry.

キーワード 推奨
  1. (英) Adrenocorticotropic Hormone
  2. (英) Aged
  3. (英) Basophils
  4. 女性(female)
  5. (英) Humans
  6. 免疫組織化学(immunohistochemistry)
  7. 男性(male)
  8. (英) Middle Aged
  9. (英) Pituitary Gland, Anterior
  10. (英) Pro-Opiomelanocortin
発行所 推奨
誌名 必須 Endocrine Pathology(Endocrine Pathology Society)
(pISSN: 1046-3976, eISSN: 1559-0097)
ISSN 任意 1046-3976
ISSN: 1046-3976 (pISSN: 1046-3976, eISSN: 1559-0097)
Title: Endocrine pathology
Title(ISO): Endocr Pathol
Supplier: Springer Online Journal Archive
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 17
必須 2
必須 155 164
都市 任意
年月日 必須 2006年 8月 10日
URL 任意
DOI 任意 10.1385/EP:17:2:155    (→Scopusで検索)
PMID 任意 17159248    (→Scopusで検索)
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指導教員 推奨
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  1. (英) Affiliation: Department of Human Pathology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.

  2. (英) PublicationType: Journal Article