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著作: Kato Yoichiro/Zembutsu Hitoshi/Takata Ryo/Matsuura Tomohiko/Kato Renpei/Kanehira Mitsugu/Iwasaki Kazuhiro/Yamada Noriyuki/[片桐 豊雅]/Sugai Tamotsu/Fujioka Tomoaki/Nakamura Yusuke/Obara Wataru/A prospective study to examine the accuracies and efficacies of prediction systems for response to neoadjuvant chemotherapy for muscle invasive bladder cancer./[Oncology Letters]

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EID
359775
EOID
963558
Map
0
LastModified
2019年9月18日(水) 16:44:12
Operator
片桐 豊雅
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片桐 豊雅
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Kato Yoichiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Zembutsu Hitoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Takata Ryo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Matsuura Tomohiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Kato Renpei
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Kanehira Mitsugu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Iwasaki Kazuhiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Yamada Noriyuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. 片桐 豊雅(副理事 (研究支援担当)/先端酵素学研究所長)
    役割 任意
    貢献度 任意
    学籍番号 推奨
  10. (英) Sugai Tamotsu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  11. (英) Fujioka Tomoaki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  12. (英) Nakamura Yusuke
    役割 任意
    貢献度 任意
    学籍番号 推奨
  13. (英) Obara Wataru
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) A prospective study to examine the accuracies and efficacies of prediction systems for response to neoadjuvant chemotherapy for muscle invasive bladder cancer.

副題 任意
要約 任意

(英) The present study established systems to predict the chemo-sensitivity of muscle invasive bladder cancer (MIBC) for neoadjuvant chemotherapy (NAC) with methotrexate, vinblastine, doxorubicin plus cisplatin (M-VAC) and carboplatin plus gemcitabine (CaG) by analyzing microarray data. The primary aim of the study was to investigate whether the clinical response would increase by combining these prediction systems. Treatment of each MIBC case was allocated into M-VAC NAC, CaG NAC, surgery, or radiation therapy groups by their prediction score (PS), which was calculated using the designed chemo-sensitivity prediction system. The therapeutic effect of the present study was compared with the results of historical controls (n=76 patients) whose treatments were not allocated using the chemo-sensitivity prediction system. In addition, the overall survival between the predicted to be responder (positive PS) group and predicted to be non-responder (negative PS) group was investigated in the present study. Of the 33 patients with MIBC, 25 cases were positive PS and 8 were negative PS. Among the 25 positive PS cases, 7 were allocated to receive M-VAC NAC and 18 were allocated to receive CaG NAC according to the results of the prediction systems. Of the 8 negative PS cases, 3 received CaG NAC, 1 received surgery without NAC and 4 received radiation therapy. The total clinical response to NAC was 88.0% (22/25), which was significantly increased compared with the historical controls [56.6% (43/76) P=0.0041]. Overall survival of the positive PS group in the study was significantly increased compared with the negative PS group (P=0.027). In conclusion, the combination of the two prediction systems may increase the treatment efficacy for patients with MIBC by proposing the optimal NAC regimen. In addition, the positive PS group would have a better prognosis compared with the negative PS group. These results suggest that the two prediction systems may lead to the achievement of 'precision medicine'.

キーワード 推奨
発行所 推奨
誌名 必須 Oncology Letters(Spandidos Publications)
(pISSN: 1792-1074, eISSN: 1792-1082)
ISSN 任意 1792-1074
ISSN: 1792-1074 (pISSN: 1792-1074, eISSN: 1792-1082)
Title: Oncology letters
Title(ISO): Oncol Lett
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 16
必須 5
必須 5775 5784
都市 任意
年月日 必須 2018年 8月 20日
URL 任意
DOI 任意 10.3892/ol.2018.9330    (→Scopusで検索)
PMID 任意 30333861    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) PublicationType: Journal Article