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著作: [宮本 理人]/身体運動と食をつなぐ生体内エネルギー調節の分子機構/[薬学雑誌]

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EID
359471
EOID
968981
Map
0
LastModified
2019年12月23日(月) 16:10:07
Operator
大家 隆弘
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宮本 理人
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種別 必須 学術論文(審査論文)
言語 必須 日本語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
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著者 必須
  1. 宮本 理人
    役割 任意
    貢献度 任意
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題名 必須

(英) AMPK as a metabolic intersection between diet and physical exercise

(日) 身体運動と食をつなぐ生体内エネルギー調節の分子機構

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(英) Physical exercise is well known to be beneficial to our health. Therapeutic exercise is widely applicable to metabolic disorders, including obesity and diabetes. In addition, recent studies have suggested its potential benefit in the treatment of more various diseases such as mental disorders and cancer. 5'AMP-activated protein kinase (AMPK), which is an intracellular central metabolic sensor as well as a regulator, has been demonstrated to play significant roles in the contracting skeletal muscles, suggesting that AMPK should be one of the key molecules mediating metabolic effects during physical exercise. Therefore, AMPK is a desirable therapeutic target for drug discovery. In the symposium S41 held in the 137th Annual Meeting of the Pharmaceutical Society of Japan, our data on the molecular mechanisms of isoform-specific postprandial suppression of AMPK activity were shared, and we discussed potential roles of AMPK as an intersection where metabolic signals by physical exercise and feeding status crosstalk. Here, I would like to introduce basic knowledge related to AMPK and recent findings regarding how AMPK activity is regulated in response to physiological and pharmacological stimulation.

キーワード 推奨
  1. (英) AMP-Activated Protein Kinases
  2. (英) Aminoimidazole Carboxamide
  3. (英) Diet
  4. (英) Drug Discovery
  5. (英) Eating
  6. (英) Exercise
  7. (英) Exercise Therapy
  8. (英) Humans
  9. (英) Hypoglycemic Agents
  10. (英) Isoenzymes
  11. (英) Metabolic Diseases
  12. (英) Metformin
  13. (英) Molecular Targeted Therapy
  14. (英) Muscle Contraction
  15. (英) Pyrones
  16. (英) Ribonucleosides
  17. (英) Thiophenes
発行所 推奨
誌名 必須 薬学雑誌([日本薬学会])
(pISSN: 0031-6903, eISSN: 1347-5231)
ISSN 任意 1347-5231
ISSN: 0031-6903 (pISSN: 0031-6903, eISSN: 1347-5231)
Title: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Title(ISO): Yakugaku Zasshi
Supplier: 公益社団法人日本薬学会
Publisher: Pharmaceutical Society of Japan
 (NLM Catalog  (Webcat Plus  (Webcat Plus  (医中誌Web  (J-STAGE  (J-STAGE  (J-STAGE  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 138
必須 10
必須 1291 1296
都市 任意
年月日 必須 2018年 0月 初日
URL 任意
DOI 任意 10.1248/yakushi.18-00091-6    (→Scopusで検索)
PMID 任意 30270274    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-85054769686
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1248/yakushi.18-00091-6

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Review

  4. (英) KeywordList.Keyword: 5-aminoimidazole-4-carboxamide-beta-riboside

  5. (英) KeywordList.Keyword: 5'AMP-activated protein kinase

  6. (英) KeywordList.Keyword: A769662

  7. (英) KeywordList.Keyword: AMP

  8. (英) KeywordList.Keyword: metabolic disease

  9. (英) KeywordList.Keyword: metformin