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著作: Shetty Abhishek/Venkatesh Thejaswini/[堤 理恵]/Suresh Padmanaban S/Regulated expression of Gemin5, Xrn1, Cpeb and Stau1 in the uterus and ovaries after superovulation and the effect of exogenous estradiol and leptin in rodents./[Molecular Biology Reports]

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2019年9月7日(土) 21:14:31
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大家 隆弘
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堤 理恵
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
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著者 必須
  1. (英) Shetty Abhishek
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    学籍番号 推奨
  2. (英) Venkatesh Thejaswini
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    貢献度 任意
    学籍番号 推奨
  3. 堤 理恵([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Suresh Padmanaban S
    役割 任意
    貢献度 任意
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題名 必須

(英) Regulated expression of Gemin5, Xrn1, Cpeb and Stau1 in the uterus and ovaries after superovulation and the effect of exogenous estradiol and leptin in rodents.

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(日) The aim of this study was to evaluate whether Gemin 5, Cpeb, Xrn1, and Stau1 expression in rodent ovaries and uterine tissues is dependent on gonadotropins, steroid hormones, and leptin in the superovulation and ovariectomized mouse models of menopause. Treatment of pregnant mare serum gonadotropin-primed rats with human chorionic gonadotropin (hCG) significantly induced Stau1 and Gemin 5 messenger RNA expression in rat ovaries. Gemin 5 expression in ovaries was sustained at relatively high levels at 12 h and 24 h post hCG treatment compared to Stau1, suggesting its role in follicle development, ovulation, and luteogenesis in rat ovaries. Induced expression of Stau1 and Gemin 5 in the uterine tissue post hCG treatment at 12 h and 24 h-the duration between ovulation and post-ovulation-suggests their regulation by hCG and/or ovarian steroids, which are required for pregnancy establishment and maintenance. Cpeb expression was significantly higher (p < 0.05) in the uterine tissues after combined treatment of estradiol and leptin at 4 h. Further, the significant upregulation of uterine Gemin 5 and Xrn1 by the synergistic activities of leptin and estradiol at 40 h in ovariectomized mice establishes them as targets of cross-talk. Although these are preliminary data, the combination of Gemin 5, Cpeb, Xrn1, and Stau1 transcript alterations in rodent ovaries and uterine tissue displayed in two different experimental models underscore their importance as therapeutic targets for anovulation or in overcoming endometrial homeostasis disturbances during pregnancy due to obesity.

キーワード 推奨
  1. (英) Animals
  2. (英) Chorionic Gonadotropin
  3. (英) Cytoskeletal Proteins
  4. (英) Estradiol
  5. (英) Exoribonucleases
  6. (英) Female
  7. (英) Gene Expression Regulation
  8. (英) Leptin
  9. (英) Microtubule-Associated Proteins
  10. (英) Ovariectomy
  11. (英) Ovary
  12. (英) Progesterone
  13. (英) RNA-Binding Proteins
  14. (英) Rats
  15. (英) Rats, Wistar
  16. (英) SMN Complex Proteins
  17. (英) Superovulation
  18. (英) Uterus
  19. (英) mRNA Cleavage and Polyadenylation Factors
発行所 推奨
誌名 必須 Molecular Biology Reports(Springer Netherlands)
(pISSN: 0301-4851, eISSN: 1573-4978)
ISSN 任意 1573-4978
ISSN: 0301-4851 (pISSN: 0301-4851, eISSN: 1573-4978)
Title: Molecular biology reports
Title(ISO): Mol Biol Rep
Supplier: Kluwer Online
Publisher: Springer Nature
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 46
必須 2
必須 2533 2540
都市 任意
年月日 必須 2019年 1月 28日
URL 任意
DOI 任意 10.1007/s11033-019-04606-z    (→Scopusで検索)
PMID 任意 30689188    (→Scopusで検索)
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  1. (英) PublicationType: Journal Article