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著作: Kurabuchi Shingo/[姚 陳娟]/[陳 剛]/[細井 和雄]/Reversible Conversion among Subtypes of Salivary Gland Duct Cells as Identified by Production of a Variety of Bioactive Polypeptides/[Acta Histochemica et Cytochemica]

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EID
358790
EOID
991565
Map
0
LastModified
2020年9月10日(木) 17:22:36
Operator
大家 隆弘
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TRUE
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Owner
細井 和雄
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種別 必須 総説·解説
言語 必須 英語
招待 推奨
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カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Kurabuchi Shingo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 姚 陳娟([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 陳 剛
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 細井 和雄
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Reversible Conversion among Subtypes of Salivary Gland Duct Cells as Identified by Production of a Variety of Bioactive Polypeptides

副題 任意
要約 任意

(英) Four major kallikreins (mK1, mK22, mK9, and mK13) were identified in the mouse submandibular gland (SMG). mK1, a true tissue kallikrein, was used as a protein marker to identify different types of SMG granular convoluted tubule (GCT) cells along with epidermal growth factor (EGF), nerve growth factor (NGF), and renin. Kallikrein mK1 was localized in a very small number (~5%) of GCT cells, which were scattered throughout the GCT, indicating that the majority of GCT cells are mK1-negative. Among mK1-positive cells, particularly strong signals were observed in a small number of narrow cells, recognized as slender granular cells (SG cells, Type IV), in the GCT. After postnatal development of the SMG, GCT cells are no longer uniform based on the bioactive substances (mK1, EGF, NGF, and renin) that they produce and secrete. GCT cells were classified into four subtypes, Types I-IV, and it became clear that these subtypes are complicatedly and reversibly converted by the endocrine hormones 5α-dihydrotestosterone (DHT) and triiodothyronine (T). Duct segments with similar morphology or hormone dependency were recognized in the sublingual and parotid glands. The presence of duct cells with such characteristics is therefore a common feature of the three major salivary glands of rodents.

キーワード 推奨
  1. (英) 5α-dihydrotestosterone
  2. (英) epidermal growth factor
  3. (英) granular convoluted tubular cells
  4. (英) mK1
  5. (英) submandibular gland
発行所 推奨
誌名 必須 Acta Histochemica et Cytochemica(日本組織細胞化学会)
(pISSN: 0044-5991, eISSN: 1347-5800)
ISSN 任意 0044-5991
ISSN: 0044-5991 (pISSN: 0044-5991, eISSN: 1347-5800)
Title: Acta histochemica et cytochemica
Title(ISO): Acta Histochem Cytochem
Supplier: 日本組織細胞化学会
Publisher: Japan Society of Histochemistry and Cytochemistry
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 52
必須 4
必須 59 65
都市 任意
年月日 必須 2019年 8月 27日
URL 任意
DOI 任意 10.1267/ahc.19014    (→Scopusで検索)
PMID 任意 31602049    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1267/ahc.19014

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Review

  4. (英) KeywordList.Keyword: 5α-dihydrotestosterone

  5. (英) KeywordList.Keyword: epidermal growth factor

  6. (英) KeywordList.Keyword: granular convoluted tubular cells

  7. (英) KeywordList.Keyword: mK1

  8. (英) KeywordList.Keyword: submandibular gland

  9. (英) CoiStatement: IXThere are no conflicts of interest to declare.