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著作: 額 惠理香/[大西 康太]/[寺尾 純二]/[河合 慶親]/ATP/P2X7 receptor signaling as a potential anti-inflammatory target of natural polyphenols./[PLoS ONE]

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EID
357162
EOID
957755
Map
0
LastModified
2019年8月20日(火) 19:13:47
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
大西 康太
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Nuka Erika / (日) 額 惠理香 / (読) ぬか えりか
    役割 任意
    貢献度 任意
    学籍番号 推奨 ****
  2. 大西 康太
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 寺尾 純二
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 河合 慶親
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) ATP/P2X7 receptor signaling as a potential anti-inflammatory target of natural polyphenols.

副題 任意
要約 任意

(英) Innate immune cells, such as macrophages, respond to pathogen-associated molecular patterns, such as a lipopolysaccharide (LPS), to secrete various inflammatory mediators. Recent studies have suggested that damage-associated molecular patterns (DAMPs), released extracellularly from damaged or immune cells, also play a role in the activation of inflammatory responses. In this study, to prevent excess inflammation, we focused on DAMPs-mediated signaling that promotes LPS-stimulated inflammatory responses, especially adenosine 5'-triphosphate (ATP)-triggered signaling through the ionotropic purinergic receptor 7 (P2X7R), as a potential new anti-inflammatory target of natural polyphenols. We focused on the phenomenon that ATP accelerates the production of inflammatory mediators, such as nitric oxide, in LPS-stimulated J774.1 mouse macrophages. Using an siRNA-mediated knockdown and specific antagonist, it was found that the ATP-induced enhanced inflammatory responses were mediated through P2X7R. We then screened 42 polyphenols for inhibiting the ATP/P2X7R-induced calcium influx, and found that several polyphenols exhibited significant inhibitory effects. Especially, a flavonoid baicalein significantly inhibited ATP-induced inflammation, including interleukin-1β secretion, through inhibition of the ATP/P2X7R signaling. These findings suggest that ATP/P2X7R signaling plays an important role in excess inflammatory responses and could be a potential anti-inflammatory target of natural polyphenolic compounds.

キーワード 推奨
  1. (英) Adenosine Triphosphate
  2. (英) Animals
  3. (英) Anti-Inflammatory Agents
  4. (英) Biological Products
  5. (英) Cell Line
  6. (英) Drug Evaluation, Preclinical
  7. (英) Flavanones
  8. (英) Interleukin-1beta
  9. (英) Lipopolysaccharides
  10. (英) Macrophages
  11. (英) Mice
  12. (英) Nitric Oxide
  13. (英) Polyphenols
  14. (英) Receptors, Purinergic P2X7
  15. (英) Signal Transduction
発行所 推奨
誌名 必須 PLoS ONE(Public Library of Science)
(eISSN: 1932-6203)
ISSN 任意 1932-6203
ISSN: 1932-6203 (eISSN: 1932-6203)
Title: PloS one
Title(ISO): PLoS One
Publisher: PLOS
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 13
必須 9
必須 e0204229 e0204229
都市 任意
年月日 必須 2018年 9月 24日
URL 任意
DOI 任意 10.1371/journal.pone.0204229    (→Scopusで検索)
PMID 任意 30248132    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1371/journal.pone.0204229

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) CoiStatement: The authors have declared that no competing interests exist.