著作: 額 惠理香/[大西 康太]/[寺尾 純二]/[河合 慶親]/ATP/P2X7 receptor signaling as a potential anti-inflammatory target of natural polyphenols./[PLoS ONE]
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削除する| 種別 | 必須 | 学術論文(審査論文) | |||
|---|---|---|---|---|---|
| 言語 | 必須 | 英語 | |||
| 招待 | 推奨 | ||||
| 審査 | 推奨 | ||||
| カテゴリ | 推奨 | ||||
| 共著種別 | 推奨 | ||||
| 学究種別 | 推奨 | ||||
| 組織 | 推奨 | ||||
| 著者 | 必須 | ||||
| 題名 | 必須 |
(英) ATP/P2X7 receptor signaling as a potential anti-inflammatory target of natural polyphenols. |
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| 副題 | 任意 | ||||
| 要約 | 任意 |
(英) Innate immune cells, such as macrophages, respond to pathogen-associated molecular patterns, such as a lipopolysaccharide (LPS), to secrete various inflammatory mediators. Recent studies have suggested that damage-associated molecular patterns (DAMPs), released extracellularly from damaged or immune cells, also play a role in the activation of inflammatory responses. In this study, to prevent excess inflammation, we focused on DAMPs-mediated signaling that promotes LPS-stimulated inflammatory responses, especially adenosine 5'-triphosphate (ATP)-triggered signaling through the ionotropic purinergic receptor 7 (P2X7R), as a potential new anti-inflammatory target of natural polyphenols. We focused on the phenomenon that ATP accelerates the production of inflammatory mediators, such as nitric oxide, in LPS-stimulated J774.1 mouse macrophages. Using an siRNA-mediated knockdown and specific antagonist, it was found that the ATP-induced enhanced inflammatory responses were mediated through P2X7R. We then screened 42 polyphenols for inhibiting the ATP/P2X7R-induced calcium influx, and found that several polyphenols exhibited significant inhibitory effects. Especially, a flavonoid baicalein significantly inhibited ATP-induced inflammation, including interleukin-1β secretion, through inhibition of the ATP/P2X7R signaling. These findings suggest that ATP/P2X7R signaling plays an important role in excess inflammatory responses and could be a potential anti-inflammatory target of natural polyphenolic compounds. |
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| キーワード | 推奨 |
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| 発行所 | 推奨 | ||||
| 誌名 | 必須 |
PLoS ONE(Public Library of Science)
(eISSN: 1932-6203)
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| 巻 | 必須 | 13 | |||
| 号 | 必須 | 9 | |||
| 頁 | 必須 | e0204229 e0204229 | |||
| 都市 | 任意 | ||||
| 年月日 | 必須 | 2018年 9月 24日 | |||
| URL | 任意 | ||||
| DOI | 任意 | 10.1371/journal.pone.0204229 (→Scopusで検索) | |||
| PMID | 任意 | 30248132 (→Scopusで検索) | |||
| CRID | 任意 | ||||
| Scopus | 任意 | ||||
| researchmap | 任意 | ||||
| 評価値 | 任意 | ||||
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| 指導教員 | 推奨 | ||||
| 備考 | 任意 |
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