徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: Mizuno Reina/[丸橋 拓海]/[杉浦 大祐]/Shimizu Kenji/Watada Mizuki/[岡崎 一美]/[岡崎 拓]/PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR./[Biochemical and Biophysical Research Communications]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
356652
EOID
956575
Map
0
LastModified
2019年8月19日(月) 11:31:18
Operator
岡崎 拓
Avail
TRUE
Censor
0
Owner
岡崎 拓
Read
継承
Write
継承
Delete
継承
種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Mizuno Reina
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 丸橋 拓海
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 杉浦 大祐
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Shimizu Kenji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Watada Mizuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 岡崎 一美
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 岡崎 拓
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR.

副題 任意
要約 任意

(英) Cancer immunotherapies targeting programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte antigen 4 revolutionized cancer treatment and instigated various trials to develop new cancer immunotherapies with higher therapeutic efficacy. Agonistic Abs against tumor necrosis factor receptor super family (TNFRSF) molecules are highly expected due to their high potential to enhance survival, proliferation, and effector function of T cells. To date, agonistic antibodies (Abs) against CD27, GITR, OX40, and 4-1BB have been reported to increase the efficacy of anti-PD-1 therapy in animal models and clinical trials of these combinatorial therapies are underway. However, the mechanisms how agonistic Abs against TNFRSF molecules potentiate anti-PD-1 therapy are not well understood. Here we examined the potency of PD-1 to inhibit the antigen-dependent activation of T cells in the presence of co-stimulation through CD27 and GITR by using in vitro and ex vivo co-culture systems of T cells and antigen presenting cells. The cytokine secretion from T cells upon antigen stimulation was strongly augmented by the engagement of CD27 or GITR with their corresponding ligands. Remarkably, PD-1 efficiently inhibited the activation of T cells even in the presence of co-stimulation through CD27 or GITR. Accordingly, cytokine secretion was synergistically augmented when PD-1 blockade was combined with triggering of CD27 or GITR. These results indicate that the triggering of TNFRSF molecules and PD-1 blockade can act on the same individual cells simultaneously to augment the magnitude of T cell activation, providing the rationale for the combinatorial usage of agonistic Abs against TNFRSF molecules and blocking Abs against PD-1 or PD-L1.

キーワード 推奨
発行所 推奨
誌名 必須 Biochemical and Biophysical Research Communications([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)
ISSN 任意 1090-2104
ISSN: 0006-291X (pISSN: 0006-291X, eISSN: 1090-2104)
Title: Biochemical and biophysical research communications
Title(ISO): Biochem Biophys Res Commun
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 511
必須 3
必須 491 497
都市 任意
年月日 必須 2019年 2月 14日
URL 任意
DOI 任意 10.1016/j.bbrc.2019.02.004    (→Scopusで検索)
PMID 任意 30771904    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: S0006-291X(19)30183-4

  2. (英) Article.ELocationID: 10.1016/j.bbrc.2019.02.004

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) KeywordList.Keyword: CD27

  5. (英) KeywordList.Keyword: Co-receptor

  6. (英) KeywordList.Keyword: GITR

  7. (英) KeywordList.Keyword: PD-1

  8. (英) KeywordList.Keyword: T cell activation

  9. (英) KeywordList.Keyword: TNF receptor super family