徳島大学 教育・研究者情報データベース(EDB)

1. 苛原 誠

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2. (英) Shinahara Wakako

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3. 杉本 真弓([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.小児科学]/[徳島大学.病院.診療科.小児·周産·女性科.小児科])

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4. (英) Ogawa Yukiko

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5. (英) Shitsukawa Keiji

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6. (英) Kubota Kenji

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7. (英) Yang Limin

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8. (英) Ohya Yukihiro

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9. (英) Saito Hirohisa

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10. 香美 祥二([徳島大学])

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11. 有澤 孝吉

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12. 木戸 博([徳島大学.先端酵素学研究所.重点研究部門])

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(英) Trajectories of class-switching-related egg and cow's milk allergen-specific immunoglobulin isotype formation and its modification by eczema with low- and high-affinity immunoglobulin E during early infancy

(英) Allergen-specific immunoglobulin isotype formation associated with immunoglobulin class-switching during the lactation period is the immunological background for food allergy in infants. We analyzed the serial changes in the production of feeding type-related egg- and milk-specific immunoglobulin isotypes from birth to 6 months of age with or without eczema in 84 infants. Allergen-specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, IgA, and IgE levels of hen's egg and bovine milk were measured in cord blood and blood samples from infants at 2, 4, and 6 months of age by the densely carboxylated protein microarray. Formula and mixed feeding were associated with a rapid increase in cow's milk allergen-specific immunoglobulins and feeding type-related significant differences in casein-specific immunoglobulin levels were detected. Breast and mixed feeding were associated with slow but significant increase in ovalbumin-specific IgG1 and IgE levels, but not other immunoglobulins. We found two different immunoglobulin isotype formation at 6 months of age with low- or high-affinity IgE against ovalbumin. One isotype formation pattern had relatively high ovalbumin-specific IgG1 levels, detectable IgG2, and low-affinity IgE, while the other had low ovalbumin-specific IgG1 levels, undetectable IgG2, and high levels of high-affinity IgE. The incidence of eczema was significantly higher in the latter pattern (84.6%), compared with the remaining infants (42.2%). Feeding practice-related allergen sensitization and immunoglobulin isotype formation were identified during the lactation period. The development of eczema during the lactation period could potentially modify the immunoglobulin isotype formation with high levels of high-affinity IgE.

1. (英) Age Factors
2. (英) Allergens
3. (英) Animals
4. (英) Antibody Affinity
5. (英) Antibody Formation
6. (英) Antibody Specificity
7. (英) Cattle
8. (英) Chickens
9. (英) Eczema
10. (英) Egg Hypersensitivity
11. (英) Eggs
12. 女性(female)
13. (英) Humans
14. (英) Immunoglobulin Class Switching
15. (英) Immunoglobulin E
16. (英) Immunoglobulin Isotypes
17. 小児(infant)
18. (英) Infant, Newborn
19. 男性(male)
20. (英) Milk
21. (英) Milk Hypersensitivity
22. (英) Pregnancy

1. (英) Article.ELocationID: 10.1002/iid3.245

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

4. (英) KeywordList.Keyword: allergen microarray

5. (英) KeywordList.Keyword: eczema

6. (英) KeywordList.Keyword: food allergy

7. (英) KeywordList.Keyword: high-affinity immunoglobulin E

8. (英) KeywordList.Keyword: immunoglobulin isotype formation

9. (英) KeywordList.Keyword: low-affinity immunoglobulin E