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著作: Muzembo Andre Basilua/Iwai-shimada Miyuki/Isobe Tomohiko/[有澤 孝吉]/Shima Masayuki/Fukushima Tetsuhito/Nakayama F. Shoji/Dioxins levels in human blood after implementation of measures against dioxin exposure in Japan/[Environmental Health and Preventive Medicine]

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EID
352741
EOID
968972
Map
0
LastModified
2019年12月23日(月) 16:04:21
Operator
三木 ちひろ
Avail
TRUE
Censor
0
Owner
有澤 孝吉
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨 国内共著(徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Muzembo Andre Basilua
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Iwai-shimada Miyuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Isobe Tomohiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 有澤 孝吉([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.予防医学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Shima Masayuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Fukushima Tetsuhito
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Nakayama F. Shoji
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Dioxins levels in human blood after implementation of measures against dioxin exposure in Japan

副題 任意
要約 任意

(英) Over the past few decades, the Japanese Ministry of the Environment has been biomonitoring dioxins in the general Japanese population and, in response to public concerns, has taken measures to reduce dioxin exposure. The objectives of this study were to assess the current dioxin dietary intake and corresponding body burden in the Japanese and compare Japanese dioxin data from 2011 to 2016 and 2002-2010 surveys. We also examined the relationship between blood dioxins and health parameters/clinical biomarkers. From 2011 to 2016, cross-sectional dioxin surveys were conducted on 490 Japanese (242 males and 248 females, aged 49.9 ± 7.6 years) from 15 Japanese prefectures. Blood (n = 490) and food samples (n = 90) were measured for 29 dioxin congeners including polychlorinated dibenzo-para-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and coplanar polychlorinated biphenyls (Co-PCBs) using gas chromatography coupled with high-resolution mass spectrometry. Using the 2006 World Health Organization toxic equivalence factors, the toxic equivalents (TEQs) were calculated. Clinical biomarkers and anthropometric parameters were also measured and information on lifestyle behaviours collected. Data imputations were applied to account for blood dioxins below the detection limit. The median (95% confidence interval or CI) blood levels and dioxin dietary intake was respectively 9.4 (8.8-9.9) pg TEQ/g lipid and 0.3 (0.2-0.4) pg TEQ/kg body weight/day. The median blood dioxin level in the 2011-2016 survey was found to have decreased by 41.3% compared to the 2002-2010 surveys. Participants who were older were found to be more likely to have higher dioxin levels. Blood dioxins were also significantly associated with body mass index, triglycerides, docosahexaenoic acid, eicosapentaenoic acid, and dihomo-gamma-linoleic acid levels in blood. Furthermore, associations between blood dioxin and dietary dioxin intake were evident in the unadjusted models. However, after adjusting for confounders, blood dioxins were not found to be associated with dietary dioxin intake. Blood dioxin levels declined over the past decade. This study showed that the measures and actions undertaken in Japan have possibly contributed to these reductions in the body burden of dioxins in the Japanese population.

キーワード 推奨
  1. (英) Dioxinx
発行所 推奨
誌名 必須 Environmental Health and Preventive Medicine(日本衛生学会)
(pISSN: 1342-078X, eISSN: 1347-4715)
ISSN 任意 1347-4715
ISSN: 1342-078X (pISSN: 1342-078X, eISSN: 1347-4715)
Title: Environmental health and preventive medicine
Title(ISO): Environ Health Prev Med
Supplier: 日本衛生学会
Publisher: Springer Japan
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 24
必須 1
必須 6 6
都市 任意
年月日 必須 2019年 1月 10日
URL 任意
DOI 任意 10.1186/s12199-018-0755-7    (→Scopusで検索)
PMID 任意 30630405    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1186/s12199-018-0755-7

  2. (英) Article.PublicationTypeList.PublicationType: Comparative Study

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) KeywordList.Keyword: Coplanar polychlorinated biphenyls

  5. (英) KeywordList.Keyword: Cross-sectional sample

  6. (英) KeywordList.Keyword: Dietary dioxin intake

  7. (英) KeywordList.Keyword: Dioxins

  8. (英) KeywordList.Keyword: Polychlorinated dibenzo-p-dioxins

  9. (英) KeywordList.Keyword: Polychlorinated dibenzofurans