徳島大学 教育・研究者情報データベース(EDB)

1. (英) Ogura Yuki / (日) 小倉 有紀 / (読) おぐら ゆき

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2. (英) Atsuta Kosuke

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3. 長谷 栄治([徳島大学.ポストLEDフォトニクス研究所])

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4. 南川 丈夫

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5. 安井 武史([徳島大学.ポストLEDフォトニクス研究所]/[徳島大学.理工学部.理工学科.機械科学コース.生産工学講座])

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(英) Photonic-Crystal-Fiber-Coupled, Hand-Held, Polarization-Resolved Second-Harmonic-Generation Microscope for In Vivo Visualization of Dermal Collagen Fibers in Human Skin

(英) Second-harmonic-generation (SHG) microscopy is a powerful tool for in vivo monitoring of collagen fibers in human skin. However, its practical use in the dermatological field is still limited due to the bulky and complicated setup. In this paper, we constructed a photonic-crystal-fiber-coupled, hand-held polarization-resolved SHG microscope for in vivo monitoring of collagen fibers in human skin. Fiber delivery of ultrashort pulse light was achieved by a large-mode-area photonic-crystal-fiber whereas the SHG microscopy setup was enclosed into a hand-held probe head. The combination of PCF with the hand-held probe head largely enhances the flexibility of measurement sites in the human skin.