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著作: 河野 友晴/[松久 宗英]/[橋田 誠一]/沼田 聡/[藤本 一幸]/[黒田 暁生]/安田 哲行/宮下 和幸/坂本 扶美枝/片上 直人/松岡 孝昭/IA-2抗体の高感度検出法(ICT-EIA法)の開発と長期罹患若年性1型糖尿病患者における3種膵島関連自己抗体(GADA,IA-2A,IAA)の検出について/[徳島文理大学研究紀要]

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EID
352298
EOID
969158
Map
0
LastModified
2019年12月25日(水) 15:11:22
Operator
三木 ちひろ
Avail
TRUE
Censor
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Owner
松久 宗英
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種別 必須 学術論文(紀要その他)
言語 必須 日本語
招待 推奨
審査 推奨
カテゴリ 推奨
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学究種別 推奨
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著者 必須
  1. (英) Kawano Tomoharu / (日) 河野 友晴
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  2. 松久 宗英([徳島大学.先端酵素学研究所.基幹研究部門]/徳島大学病院アンチエイジングセンター センター長(併任))
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  3. 橋田 誠一([宮崎医科大学])
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  4. (英) Numata Satoshi / (日) 沼田 聡
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  5. 藤本 一幸
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  6. 黒田 暁生([徳島大学.先端酵素学研究所.基幹研究部門])
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    学籍番号 推奨
  7. (英) Yasuda Tetsuyuki / (日) 安田 哲行
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  8. (英) Miyashita Kazuyuki / (日) 宮下 和幸
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  9. (英) Sakamoto Fumie / (日) 坂本 扶美枝
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  10. (英) Katakami Naoto / (日) 片上 直人
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  11. (英) Matsuoka Taka-aki / (日) 松岡 孝昭
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題名 必須

(英) Development of highly sensitive enzyme immunoassay (ICT-EIA) for IA-2 autoantibody and application for detection of three islet-specific autoantibodies ( GADA, IA-2A and IAA) in type I diabetes mellitus

(日) IA-2抗体の高感度検出法(ICT-EIA法)の開発と長期罹患若年性1型糖尿病患者における3種膵島関連自己抗体(GADA,IA-2A,IAA)の検出について

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要約 任意

(英) <p>Development of highly sensitive enzyme immunoassay (ICT-EIA) for IA-2 autoantibody and application for detection of three islet-specific autoantibodies ( GADA, IA-2A and IAA) in type I diabetes mellitus Tomoharu Kawano, Satoshi Numata, Yuki Fujimoto, Akio Kuroda, Tetsuyuki Yasuda,Kazuyuki Miyashita, Fumie Sakamoto, Naoto Katakami, Taka-aki Matsuoka, Munehide Matsuhisa and Seiichi Hashida Summary Detection of pancreatic islet-related autoantibodies( insulin antibody [IAA]; glutamic acid decarboxylase antibody [GADA]; and islet antigen-2 antibody [IA-2A], is essential for the diagnosis and prediction of the onset of type I diabetes mellitus. Depending on the disease duration, the detection rate of each autoantibody is different, and using only one kind of autoantibody detection risks overlooking a positive result. The detection precision of type I diabetes mellitus would thus be improved by measuring all three kinds of autoantibodies. We developed a highly sensitive enzyme immunoassay( ICT-EIA) for IA-2 autoantibody. ICT-EIAs for IAA and GADA have already been developed. Using three ICT-EIAs, we attempted to measure autoantibodies in sera from patients with type I diabetes mellitus. Patients comprised 25 males and 51 females( mean age, 33.3±5.7 years; disease duration, 23.9±6.7 years) with type I diabetes mellitus who had been undergoing treatment with insulin for between 11 and 40 years. Among these patients, urinary C-peptide-positive results were seen in three patients. IAA, GADA and IA-2A in sera were measured by ICT-EIA. The newly developed ICT-EIA for IA-2 antibodies was approximately 100-times more sensitive than the conventional ELISA. The positive ratio was 77.6%, representing a high rate of detection. In addition, even in patients with a disease duration >30 years, the positive rate was 64.3%. ICT-EIA was thus suggested to be useful in combination assays for pancreatic islet-related autoantibodies (IAA, GADA and IA-2A).</p><p> </p><p></p>

(日) <p>Development of highly sensitive enzyme immunoassay (ICT-EIA) for IA-2 autoantibody and application for detection of three islet-specific autoantibodies ( GADA, IA-2A and IAA) in type I diabetes mellitus Tomoharu Kawano, Satoshi Numata, Yuki Fujimoto, Akio Kuroda, Tetsuyuki Yasuda,Kazuyuki Miyashita, Fumie Sakamoto, Naoto Katakami, Taka-aki Matsuoka, Munehide Matsuhisa and Seiichi Hashida Summary Detection of pancreatic islet-related autoantibodies( insulin antibody [IAA]; glutamic acid decarboxylase antibody [GADA]; and islet antigen-2 antibody [IA-2A], is essential for the diagnosis and prediction of the onset of type I diabetes mellitus. Depending on the disease duration, the detection rate of each autoantibody is different, and using only one kind of autoantibody detection risks overlooking a positive result. The detection precision of type I diabetes mellitus would thus be improved by measuring all three kinds of autoantibodies. We developed a highly sensitive enzyme immunoassay( ICT-EIA) for IA-2 autoantibody. ICT-EIAs for IAA and GADA have already been developed. Using three ICT-EIAs, we attempted to measure autoantibodies in sera from patients with type I diabetes mellitus. Patients comprised 25 males and 51 females( mean age, 33.3±5.7 years; disease duration, 23.9±6.7 years) with type I diabetes mellitus who had been undergoing treatment with insulin for between 11 and 40 years. Among these patients, urinary C-peptide-positive results were seen in three patients. IAA, GADA and IA-2A in sera were measured by ICT-EIA. The newly developed ICT-EIA for IA-2 antibodies was approximately 100-times more sensitive than the conventional ELISA. The positive ratio was 77.6%, representing a high rate of detection. In addition, even in patients with a disease duration >30 years, the positive rate was 64.3%. ICT-EIA was thus suggested to be useful in combination assays for pancreatic islet-related autoantibodies (IAA, GADA and IA-2A).</p><p> </p><p></p>

キーワード 推奨
発行所 推奨 徳島文理大学
誌名 必須 徳島文理大学研究紀要([徳島文理大学])
(pISSN: 0286-9829)
ISSN 任意 0286-9829
ISSN: 0286-9829 (pISSN: 0286-9829)
Title: 徳島文理大学研究紀要
Supplier: 徳島文理大学
 (Webcat Plus  (医中誌Web (No Scopus information.)
必須 96
必須 ---
必須 35 44
都市 任意
年月日 必須 2018年 9月 初日
URL 任意 https://ci.nii.ac.jp/naid/130007602165/
DOI 任意 10.24596/tokusimabunriu.96.0_35    (→Scopusで検索)
PMID 任意
NAID 任意 130007602165
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
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